Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3445325 | 0.90 | KDM4E (0.76) | KDM4EMAPTCHRNB2CHRNA4LMNA | |
| SCHEMBL9808215 | 0.82 | LMNA (0.67) | KDM4ELMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL30642985 | 0.81 | MAPT (1.00) | KDM4EMAPTCHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL8360713 | 0.80 | CHRNB2 (0.67) | KDM4EMAPTCHRNB2CHRNA4LMNA | |
| SCHEMBL16858365 | 0.80 | CHRNB2 (0.67) | KDM4EMAPTCHRNB2CHRNA4LMNA | |
| SCHEMBL30862627 | 0.80 | CHRNB2 (0.67) | KDM4ECHRNB2CHRNA4LMNAALDH1A1 | |
| SCHEMBL5025139 | 0.80 | CHRNB2 (0.67) | KDM4ECHRNB2CHRNA4LMNAALDH1A1 | |
| SCHEMBL196962 | 0.79 | KMT2A (0.68) | KDM4EMAPTLMNAMAPK1HTT | |
| SCHEMBL7222639 | 0.79 | CHRNB2 (0.65) | KDM4EMAPTCHRNB2CHRNA4LMNA | |
| SCHEMBL18186482 | 0.79 | CHRNB2 (0.65) | KDM4EMAPTCHRNB2CHRNA4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735406-B2 | 8-oxodihydropurine derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2014-05-27 | — | — | US | disclosed |
| US-8735406-B2 | 8-oxodihydropurine derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2014-05-27 | — | — | US | disclosed |
| US-20120172347-A1 | 8-OXODIHYDROPURINE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-05 | — | — | US | disclosed |
| US-20120172347-A1 | 8-OXODIHYDROPURINE DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172347-A1 | 8-OXODIHYDROPURINE DERIVATIVE | FAAH, FAAH2, TPMT | KDM4E 1314/4885MAPT 2670/4885CHRNB2 3125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.