Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1026412 | 1.00 | KMT2A (0.58) | KMT2AHTTMEN1LMNAL3MBTL1 | |
| SCHEMBL1026260 | 0.82 | ALDH1A1 (0.48) | KMT2AHTTMEN1LMNAL3MBTL1 | |
| SCHEMBL1026262 | 0.82 | ALDH1A1 (0.48) | KMT2AHTTMEN1LMNAL3MBTL1 | |
| SCHEMBL1028886 | 0.77 | L3MBTL1 (0.49) | HTTLMNAL3MBTL1SMN1; SMN2GPR35 | |
| SCHEMBL1028889 | 0.77 | L3MBTL1 (0.49) | HTTLMNAL3MBTL1SMN1; SMN2GPR35 | |
| SCHEMBL205059 | 0.76 | MEN1 (1.00) | KMT2AHTTMEN1LMNAL3MBTL1 | |
| SCHEMBL12095462 | 0.75 | MEN1 (0.95) | KMT2AHTTMEN1LMNAL3MBTL1 | |
| SCHEMBL17221822 | 0.74 | HTT (0.43) | KMT2AHTTMEN1LMNAL3MBTL1 | |
| SCHEMBL16735812 | 0.73 | ALDH1A1 (0.44) | KMT2AHTTMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL3509381 | 0.73 | ALDH1A1 (0.46) | KMT2AHTTMEN1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |