Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12921206 | 0.92 | CRHR1 (0.32) | TLR8TLR7KCNH2 | |
| SCHEMBL186581 | 0.92 | CCR1 (0.35) | — | |
| SCHEMBL10268880 | 0.86 | CRHR1 (0.32) | — | |
| SCHEMBL591223 | 0.79 | TLR8 (0.32) | TLR8TLR7 | |
| SCHEMBL4072273 | 0.79 | CETP (0.37) | TLR8TLR7 | |
| SCHEMBL12921203 | 0.79 | ALDH1A1 (0.32) | — | |
| SCHEMBL9267989 | 0.79 | TLR8 (0.35) | TLR8TLR7KCNH2 | |
| SCHEMBL187793 | 0.78 | CCR1 (0.34) | KCNH2 | |
| SCHEMBL7708685 | 0.78 | CCR1 (0.34) | KCNH2 | |
| SCHEMBL12921221 | 0.78 | KDM4E (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215092-B1 | SUBSTITUTED PIPERIDINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INT (DE) | 2012-01-25 | — | — | EP | disclosed |