Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072273 | 0.87 | CETP (0.37) | TLR8TLR7KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12872225 | 0.86 | MAT2A (0.35) | KDM4ELMNAALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL8033487 | 0.86 | MAT2A (0.35) | KDM4ELMNAALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL591223 | 0.83 | TLR8 (0.32) | TLR8TLR7HTR2ACRHR1 | |
| SCHEMBL1185833 | 0.82 | PHGDH (0.39) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL186581 | 0.82 | CCR1 (0.35) | DRD2MAPT | |
| SCHEMBL12921206 | 0.79 | CRHR1 (0.32) | TLR8TLR7KCNH2CRHR1 | |
| SCHEMBL10266442 | 0.79 | TLR8 (0.33) | TLR8TLR7KCNH2 | |
| SCHEMBL1186159 | 0.78 | ALDH1A1 (0.32) | KDM4ELMNAALDH1A1SMN1; SMN2DRD2 | |
| SCHEMBL557666 | 0.78 | TLR8 (0.34) | TLR8TLR7KCNH2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214673-B1 | PHENYL-SUBSTITUTED PIPERAZINO-DIHYDROTHIENOPYRIMIDINES | BOEHRINGER INGELHEIM INT (DE) | 2012-05-30 | — | — | EP | disclosed |