Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1441524 | 0.82 | NPSR1 (0.43) | NPSR1CRHR1HSD17B10RAB9ANPC1 | |
| SCHEMBL1441523 | 0.82 | NPSR1 (0.43) | NPSR1CRHR1HSD17B10RAB9ANPC1 | |
| SCHEMBL17700718 | 0.81 | CRHR1 (0.51) | NPSR1CRHR1HSD17B10RAB9ANPC1 | |
| SCHEMBL23028601 | 0.73 | CCNT1 (0.47) | NPSR1CRHR1HSD17B10RAB9ANPC1 | |
| SCHEMBL17662610 | 0.71 | NPSR1 (0.50) | NPSR1CRHR1HSD17B10RAB9ANPC1 | |
| SCHEMBL24347521 | 0.69 | NPSR1 (0.49) | NPSR1CRHR1HSD17B10RAB9ANPC1 | |
| SCHEMBL2324870 | 0.68 | GRM5 (0.57) | NPSR1HSD17B10RAB9ANPC1L3MBTL1 | |
| SCHEMBL9949733 | 0.68 | ALDH1A1 (0.50) | CRHR1TSHRGRM5ALDH1A1GAA | |
| SCHEMBL19122317 | 0.67 | NPSR1 (0.46) | NPSR1CRHR1HSD17B10RAB9ANPC1 | |
| SCHEMBL18886138 | 0.67 | NPSR1 (0.53) | NPSR1HSD17B10RAB9ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | NOVARTIS AG (CH) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | ETV6, CYP11B2, CYP11B1 | NPSR1 3193/4885CRHR1 2360/4885HSD17B10 478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.