Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.65 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.65 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10219039 | 0.92 | CYP3A4 (0.78) | CYP3A4ABCC4ABCB11CYP3A5PTGS1 | |
| SCHEMBL13655585 | 0.82 | CYP3A4 (0.61) | CYP3A4ABCC4ABCB11CYP3A5PTGS1 | |
| SCHEMBL799508 | 0.82 | CYP3A4 (0.61) | CYP3A4ABCC4ABCB11CYP3A5PTGS1 | |
| SCHEMBL14625955 | 0.81 | CYP3A4 (0.73) | CYP3A4ABCC4ABCB11CYP3A5PTGS1 | |
| SCHEMBL799164 | 0.81 | CYP3A4 (0.58) | CYP3A4ABCC4ABCB11CYP3A5PTGS1 | |
| SCHEMBL14625966 | 0.81 | CYP3A4 (0.72) | CYP3A4ABCC4ABCB11CYP3A5PTGS1 | |
| SCHEMBL13655659 | 0.80 | CYP3A4 (0.59) | CYP3A4ABCC4ABCB11CYP3A5PTGS1 | |
| SCHEMBL14626124 | 0.80 | CYP3A4 (0.71) | CYP3A4ABCC4ABCB11CYP3A5PTGS1 | |
| SCHEMBL14625970 | 0.80 | CYP3A4 (0.71) | CYP3A4ABCC4ABCB11CYP3A5PTGS1 | |
| SCHEMBL14626514 | 0.80 | CYP3A4 (0.71) | CYP3A4ABCC4ABCB11CYP3A5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124744-B2 | Macrolide derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |
| US-20090076253-A1 | MACROLIDE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076253-A1 | MACROLIDE DERIVATIVES | MMP9, MMP2, MMP11 | CYP3A4 1429/4885ABCC4 1042/4885ABCB11 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.