Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10270565 | 0.83 | ALDH1A1 (0.33) | OPRL1ROCK2ROCK1OPRM1 | |
| SCHEMBL15199090 | 0.78 | CYP2C9 (0.34) | — | |
| SCHEMBL8070148 | 0.78 | OPRL1 (0.31) | OPRL1ROCK2ROCK1 | |
| SCHEMBL23903956 | 0.78 | OPRL1 (0.34) | OPRL1ROCK2ROCK1OPRM1 | |
| SCHEMBL15199091 | 0.78 | CYP2C9 (0.34) | — | |
| SCHEMBL13451458 | 0.76 | — | — | |
| SCHEMBL14652117 | 0.74 | KDM5A (0.38) | OPRL1ROCK2ROCK1OPRM1 | |
| SCHEMBL17029398 | 0.73 | POLB (0.33) | — | |
| SCHEMBL16015291 | 0.70 | SMN1; SMN2 (0.41) | — | |
| SCHEMBL14671061 | 0.68 | CHRNB2 (0.33) | OPRL1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012018668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2012-02-09 | — | — | WO | disclosed |