SCHEMBL10270726

SCHEMBL10270726

N#Cc1ccc(CF)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.58
CYP2A6 P11509 2/20 0.58
MAOB P27338 4/20 0.47
MAOA P21397 2/20 0.47
CYP19A1 P11511 2/20 0.47
KCNJ1 P48048 1/20 0.47
KCNH2 Q12809 1/20 0.47
ALDH1A1 P00352 1/20 0.46
CA12 O43570 1/20 0.46
CA2 P00918 1/20 0.46
CA3 P07451 1/20 0.46
CA6 P23280 1/20 0.46
CA9 Q16790 1/20 0.46
CA14 Q9ULX7 1/20 0.46
IDO1 P14902 2/20 0.45
TSHR P16473 2/20 0.43
SAE1 Q9UBE0 1/20 0.42
UBA2 Q9UBT2 1/20 0.42
HTT P42858 1/20 0.42
HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9552723 0.93 LOXL2 (0.52) LOXL2CYP2A6MAOBMAOACYP19A1
SCHEMBL9553015 0.93 LOXL2 (0.52) LOXL2CYP2A6MAOBMAOACYP19A1
SCHEMBL9553356 0.93 LOXL2 (0.52) LOXL2CYP2A6MAOBMAOACYP19A1
SCHEMBL12229945 0.84 CYP2A6 (0.48) LOXL2CYP2A6MAOBMAOACYP19A1
SCHEMBL2517860 0.84 LSS (0.47) LOXL2CYP2A6MAOBMAOACYP19A1
SCHEMBL14764212 0.80 LOXL2 (0.60) LOXL2CYP2A6MAOBMAOACYP19A1
SCHEMBL1004267 0.78 LOXL2 (0.64) LOXL2CYP2A6MAOBMAOACYP19A1
SCHEMBL1344068 0.78 LOXL2 (0.65) LOXL2CYP2A6MAOBMAOACYP19A1
SCHEMBL45942 0.76 CA2 (0.69) LOXL2CYP2A6MAOBMAOAALDH1A1
SCHEMBL2503454 0.76 CA2 (0.69) LOXL2CYP2A6MAOBMAOAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119462506-A Long-chain ketonitrile compound and preparation method and application thereof 华东理工大学 2025-02-18 CN disclosed
CN-118932350-A Method for synthesizing carboxylic acid and deuterated carboxylic acid compound through electrochemical defluorination 江西师范大学 2024-11-12 CN disclosed
CN-117106003-A Preparation method of organic fluorine compound 浙江工业大学 2023-11-24 CN disclosed
CN-114105722-B Method for preparing organic fluorine compound 浙江工业大学 2023-10-20 CN disclosed
CN-114105722-A Method for preparing organic fluorine compound 浙江工业大学 2022-03-01 CN disclosed
US-20210155561-A1 METHOD AND REAGENT FOR DEOXYFLUORINATION SOUTH DAKOTA BOARD OF REGENTS (US) 2021-05-27 US disclosed
US-20210155561-A1 METHOD AND REAGENT FOR DEOXYFLUORINATION SOUTH DAKOTA BOARD OF REGENTS (US) 2021-05-27 US disclosed
WO-2020037109-A1 PROCESSES FOR FLUORINATION DOW AGROSCIENCES LLC (US) 2020-02-20 WO disclosed
CN-110506040-A Kill the oxadiazole derivatives of microorganism SYNGENTA PARTICIPATIONS AG 2019-11-26 CN disclosed
CN-106573927-B Oxyclohepten-2-yl-pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use 豪夫迈·罗氏有限公司 2019-09-27 CN disclosed
CN-105658628-A Novel arylalkene derivatives and use thereof as selective estrogen receptor modulators 北京赛林泰医药技术有限公司 2016-06-08 CN disclosed
CN-105283439-A BORON-CONTAINING DIACYLHYDRAZINES INTREXON CORP 2016-01-27 CN disclosed
CN-104640858-A Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use HOFFMANN LA ROCHE 2015-05-20 CN disclosed
CN-102209717-B Compounds for the treatment of hepatitis c BRISTOL MYERS SQUIBB CO 2015-02-18 CN disclosed
CN-104080771-A Apoptosis signal-regulating kinase inhibitors GILEAD SCIENCES INC 2014-10-01 CN disclosed
CN-103261167-A Substituted 6,6-used nitrogenous heterocyclic compounds and uses thereof HOFFMANN LA ROCHE 2013-08-21 CN disclosed
EP-2137188-B1 SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES Bayer Pharma AG (DE) 2012-06-06 EP disclosed
EP-1465880-B1 5-SULPHANYL-4H-1,2,4-TRIAZOLE DERIVATIVES AND THEIR USE TO TREAT DISORDERS ASSOCIATED WITH SOMATOSTATINE IPSEN PHARMA (FR) 2009-08-05 EP disclosed
EP-1467974-B1 BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS GNRH ANTAGONISTS SOD CONSEILS RECH APPLIC (FR) 2007-08-15 EP disclosed
US-4051168-A TO FORM FLUOROALKYL AROMATIC COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-09-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210155561-A1 METHOD AND REAGENT FOR DEOXYFLUORINATION PFAS, FIBP, NPFFR2 LOXL2 3429/4885CYP2A6 2204/4885MAOB 844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.