Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | VDR | P11473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL955492 | 0.86 | CYP2C19 (0.43) | CYP2C19KMT2AALDH1A1MEN1ESR2 | |
| SCHEMBL13160701 | 0.85 | CYP3A4 (0.42) | CYP2C19KMT2AALDH1A1MEN1STAT3 | |
| SCHEMBL14132017 | 0.83 | CYP2C19 (0.42) | CYP2C19KMT2AALDH1A1ESR2ESR1 | |
| SCHEMBL14131699 | 0.81 | CYP2C19 (0.43) | CYP2C19KMT2AALDH1A1MEN1ESR2 | |
| SCHEMBL2759905 | 0.81 | ALDH1A1 (0.51) | CYP2C19KMT2AALDH1A1MEN1ESR2 | |
| SCHEMBL26906466 | 0.81 | ALDH1A1 (0.51) | CYP2C19KMT2AALDH1A1MEN1ESR2 | |
| SCHEMBL13557890 | 0.81 | ALDH1A1 (0.56) | CYP2C19KMT2AALDH1A1MEN1ESR2 | |
| SCHEMBL10555434 | 0.81 | CYP1A2 (0.49) | CYP2C19KMT2AALDH1A1MEN1STAT3 | |
| SCHEMBL547325 | 0.81 | RECQL (0.46) | CYP2C19KMT2AALDH1A1MEN1STAT3 | |
| SCHEMBL25340178 | 0.80 | CYP24A1 (0.39) | CYP2C19KMT2AALDH1A1MEN1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274287-B1 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS INC (US) | 2016-03-09 | — | — | EP | disclosed |
| US-20110105504-A1 | Inhibitors Of 11beta-Hydroxysteroid Dehydrogenase Type 1 | Vitae Pharmaceuticals ,Inc. | 2011-05-05 | — | — | US | disclosed |
| US-20110105504-A1 | Inhibitors Of 11beta-Hydroxysteroid Dehydrogenase Type 1 | Vitae Pharmaceuticals ,Inc. | 2011-05-05 | — | — | US | disclosed |
| US-20110105504-A1 | Inhibitors Of 11beta-Hydroxysteroid Dehydrogenase Type 1 | Vitae Pharmaceuticals ,Inc. | 2011-05-05 | — | — | US | disclosed |
| EP-2274287-A1 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | Vitae Pharmaceuticals, Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009117109-A1 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117109-A1 | INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105504-A1 | Inhibitors Of 11beta-Hydroxysteroid Dehydrogenase Type 1 | HSD11B1, HSD17B1, HSD11B2 | CYP2C19 115/4885KMT2A 3473/4885ALDH1A1 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.