Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 16/20 | 0.53 |
| ▸ | CA1 | P00915 | 15/20 | 0.53 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 13/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 11/20 | 0.44 |
| ▸ | LDHA | P00338 | 5/20 | 0.43 |
| ▸ | LDHB | P07195 | 5/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272213 | 0.81 | CA2 (0.53) | CA2CA1CA13CA7CA9 | |
| SCHEMBL10272212 | 0.80 | CA1 (0.51) | CA2CA1CA13CA7CA9 | |
| SCHEMBL10271843 | 0.75 | GAA (0.43) | GAALDHALDHBMEN1LMNA | |
| SCHEMBL10272209 | 0.73 | CDK7 (0.44) | GAACCNA2CDK2CCNA1MEN1 | |
| SCHEMBL10272182 | 0.73 | CA1 (0.47) | CA2CA1CA13CA7CA9 | |
| SCHEMBL10272163 | 0.68 | GAA (0.56) | GAAMEN1LMNAHPGDKMT2A | |
| SCHEMBL10466353 | 0.66 | GAA (1.00) | GAAMEN1LMNAHPGDKMT2A | |
| SCHEMBL10271853 | 0.66 | GAA (0.70) | GAAMEN1LMNAHPGDKMT2A | |
| SCHEMBL27888182 | 0.64 | CA1 (0.71) | CA2CA1CA7CA9CA12 | |
| SCHEMBL4861850 | 0.64 | PTGS2 (0.47) | CA2CA1CA9GAACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |