Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.39 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10275758 | 0.91 | PDE2A (0.40) | PDE2A | |
| SCHEMBL10313601 | 0.86 | ATM (0.40) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10275292 | 0.82 | KIF11 (0.46) | KIF11GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10275326 | 0.82 | AR (0.46) | — | |
| SCHEMBL10275919 | 0.80 | CNR1 (0.38) | CNR1PDE2ACYP3A4SLC34A1 | |
| SCHEMBL10276100 | 0.78 | KIF11 (0.39) | KIF11GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10313488 | 0.76 | ALDH1A1 (0.34) | CYP3A4 | |
| SCHEMBL10275596 | 0.76 | PGR (0.38) | KIF11PDE2ACYP3A4 | |
| SCHEMBL10275587 | 0.75 | CYP3A4 (0.42) | CNR1CYP3A4 | |
| SCHEMBL10313530 | 0.72 | CNR1 (0.37) | CNR1KCNH2CYP3A4SLC34A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554111-A | Aromatic heterocyclic pyridine derivatives and analogs, and preparation method and application thereof | LIAONING LIFENG SCIENCE AND TECHNOLOGY DEV CO LTD | 2014-02-05 | — | — | CN | claimed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | claimed |
| CN-101671336-A | Aromatic heterocyclic pyrimidine derivative and analogue, preparation method and application thereof | LIAONING LIFENG SCIENCE AND TE | 2010-03-17 | — | — | CN | claimed |
| CN-103554111-A | Aromatic heterocyclic pyridine derivatives and analogs, and preparation method and application thereof | LIAONING LIFENG SCIENCE AND TECHNOLOGY DEV CO LTD | 2014-02-05 | — | — | CN | disclosed |
| CN-101671336-B | Aromatic heterocyclic pyrimidine derivative and analogue, preparation method and application thereof | LIAONING LIFENG SCIENCE AND TECHNOLOGY DEV CO LTD | 2013-11-13 | — | — | CN | disclosed |
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | XU LIFENG (US) | 2012-07-12 | — | — | US | disclosed |
| WO-2011035518-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | 辽宁利锋科技开发有限公司 (CN) | 2011-03-31 | — | — | WO | disclosed |
| CN-101671336-A | Aromatic heterocyclic pyrimidine derivative and analogue, preparation method and application thereof | LIAONING LIFENG SCIENCE AND TE | 2010-03-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178915-A1 | PYRIMIDINE DERIVATIVES AND ANALOGS, PREPARATION METHOD AND USE THEREOF | TYMP, TYMS, ADORA3 | KIF11 4069/4885GABRP 938/4885GABRD 1575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.