Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24362288 | 0.92 | MAOA (0.38) | MAOBPTGS2DRD2DRD3 | |
| SCHEMBL29600396 | 0.92 | MAOA (0.38) | MAOBPTGS2DRD2DRD3 | |
| SCHEMBL4809246 | 0.84 | MEN1 (0.41) | PTGS2 | |
| SCHEMBL2303778 | 0.84 | MEN1 (0.41) | PTGS2 | |
| SCHEMBL4808936 | 0.83 | MAOB (0.39) | MAOBPTGS2DRD2HTR1DDRD3 | |
| SCHEMBL12533716 | 0.79 | STS (0.36) | DRD2HTR1DDRD3 | |
| SCHEMBL4517278 | 0.78 | RXRA (0.34) | — | |
| SCHEMBL29600467 | 0.76 | MAOA (0.38) | MAOBPTGS2DRD2 | |
| SCHEMBL24362492 | 0.76 | MAOA (0.38) | MAOBPTGS2DRD2 | |
| SCHEMBL7501392 | 0.76 | MEN1 (0.39) | MAOBPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581509-B1 | 1-(AMINO)INDANES AS EDG RECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2011-01-19 | — | — | EP | disclosed |
| EP-1581509-A4 | 1-(AMINO)INDANES AND (1,2-DIHYDRO-3-AMINO)-BENZOFURANS, BENZOTHIOPHENES AND INDOLES AS EDG RECEPTOR AGONISTS | MERCK & CO INC (US) | 2008-04-23 | — | — | EP | disclosed |
| US-7220734-B2 | 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists | MERCK & CO., INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20060161005-A1 | 1-(Amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists | MERCK SHARP & DOHME CORP. | 2006-07-20 | — | — | US | disclosed |
| EP-1581509-A2 | 1-(AMINO)INDANES AND (1,2-DIHYDRO-3-AMINO)-BENZOFURANS, BENZOTHIOPHENES AND INDOLES AS EDG RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058149-A2 | 1-(AMINO)INDANES AND (1,2-DIHYDRO-3-AMINO)-BENZOFURANS, BENZOTHIOPHENES AND INDOLES | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060161005-A1 | 1-(Amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists | IDO1, IDO2, EDNRA | MAOB 1511/4885PTGS2 619/4885DRD2 1409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.