Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 13/20 | 0.38 |
| ▸ | MAOB | P27338 | 13/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29600467 | 0.97 | MAOA (0.38) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL24362492 | 0.97 | MAOA (0.38) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL29600396 | 0.82 | MAOA (0.38) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL24362288 | 0.82 | MAOA (0.38) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL315565 | 0.78 | MAOB (0.55) | MAOAMAOBPRKCIGRM5HSD17B1 | |
| SCHEMBL1513290 | 0.77 | MAOA (0.53) | MAOAMAOBCYP2A6 | |
| SCHEMBL11461839 | 0.76 | HSD17B1 (0.49) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL30558410 | 0.76 | HSD17B1 (0.49) | MEN1MAPK1KMT2ANPSR1MAOA | |
| SCHEMBL1027802 | 0.76 | MAOB (0.37) | MAOBPTGS2 | |
| SCHEMBL15205858 | 0.76 | MAOB (0.39) | NPSR1MAOAMAOBGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721942-B1 | TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO KK (JP) | 2002-06-05 | — | — | EP | disclosed |
| US-5646283-A | IMMUNOSUPPRESSANTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-08 | — | — | US | disclosed |
| EP-0721942-A1 | NOVEL TETRACYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-07-17 | — | — | EP | disclosed |