Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 6/20 | 0.49 |
| ▸ | NOS1 | P29475 | 6/20 | 0.49 |
| ▸ | NOS3 | P29474 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 2/20 | 0.46 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21590080 | 0.89 | NOS3 (0.60) | NOS2NOS1NOS3KMT2AMEN1 | |
| SCHEMBL21590077 | 0.89 | NOS3 (0.60) | NOS2NOS1NOS3KMT2AMEN1 | |
| SCHEMBL10279979 | 0.84 | NOS2 (0.51) | NOS2NOS1NOS3KMT2AMEN1 | |
| SCHEMBL21250709 | 0.83 | NOS2 (0.47) | NOS2NOS1NOS3KMT2AMEN1 | |
| SCHEMBL21335891 | 0.81 | GSR (0.48) | NOS2NOS1NOS3KMT2AMEN1 | |
| SCHEMBL10279976 | 0.81 | GSR (0.56) | NOS2NOS1NOS3KMT2AMEN1 | |
| SCHEMBL26747924 | 0.81 | GSR (0.56) | NOS2NOS1NOS3KMT2AMEN1 | |
| SCHEMBL14508685 | 0.80 | DDAH1 (0.54) | NOS2NOS1NOS3KMT2AMEN1 | |
| SCHEMBL31369975 | 0.79 | GSR (0.67) | NOS2NOS1NOS3KMT2AMEN1 | |
| SCHEMBL25661126 | 0.79 | GSR (0.50) | NOS2NOS1NOS3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024452-A2 | MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES | AMBRX, INC. (US) | 2012-02-23 | — | — | WO | disclosed |