Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7914471 | 0.89 | NPC1 (0.47) | KDM4EMAPTALDH1A1HPGDEGFR | |
| SCHEMBL12553304 | 0.87 | EGFR (0.56) | KDM4ECYP2C19CYP1A2CYP2C9MAPT | |
| SCHEMBL1390667 | 0.83 | MAPT (0.47) | KDM4ECYP2D6CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL4304248 | 0.81 | MAPT (0.51) | KDM4ECYP2D6CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL7923604 | 0.81 | CHEK1 (0.47) | KDM4ECYP2D6CYP2C19CYP1A2CYP2C9 | |
| SCHEMBL7922447 | 0.80 | TDP1 (0.51) | KDM4EMAPTALDH1A1HPGDEGFR | |
| SCHEMBL12553298 | 0.78 | CA12 (0.57) | CYP2C19CYP1A2CYP2C9MAPTBACE1 | |
| SCHEMBL12587316 | 0.78 | MAOA (0.49) | KDM4ECYP2C19CYP1A2CYP2C9MAPT | |
| SCHEMBL7920254 | 0.77 | PLA2G2A (0.51) | KDM4ECYP2D6MAPTALDH1A1HPGD | |
| SCHEMBL7928723 | 0.77 | PLA2G2A (0.50) | KDM4EMAPTALDH1A1HPGDEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010247-A1 | BICYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010247-A1 | BICYCLIC COMPOUND | ACACA, CPT1B, ACACB | KDM4E 1415/4885CYP2D6 3309/4885CYP2C19 2942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.