Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | CA12 | O43570 | 6/20 | 0.62 |
| ▸ | CA2 | P00918 | 6/20 | 0.62 |
| ▸ | CA9 | Q16790 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | MPO | P05164 | 5/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ADH1B | P00325 | 1/20 | 0.52 |
| ▸ | ADH1C | P00326 | 1/20 | 0.52 |
| ▸ | ADH1A | P07327 | 1/20 | 0.52 |
| ▸ | ADH7 | P40394 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8763191 | 0.84 | ADH1B (0.62) | TSHRCYP2D6HIF1ACA12CA2 | |
| SCHEMBL30595834 | 0.84 | ADH1B (0.62) | TSHRCYP2D6HIF1ACA12CA2 | |
| SCHEMBL5072950 | 0.80 | MPO (0.61) | TSHRCYP2D6HIF1ACA12CA2 | |
| SCHEMBL2733931 | 0.80 | TSHR (0.61) | TSHRCYP2D6HIF1ACA12CA2 | |
| SCHEMBL460754 | 0.80 | TSHR (1.00) | TSHRCYP2D6HIF1ACA12CA2 | |
| SCHEMBL8763256 | 0.78 | ADH1B (0.56) | TSHRCYP2D6HIF1ACA12CA2 | |
| Catechol SCHEMBL27790303 | 0.78 | ADH1B (0.80) | CA12CA2MPOPKMADH1B | |
| SCHEMBL7294140 | 0.77 | MPO (0.64) | TSHRCYP2D6HIF1ACA12CA2 | |
| SCHEMBL8379179 | 0.77 | ADH1B (0.54) | TSHRCYP2D6HIF1ACA12CA2 | |
| SCHEMBL5546697 | 0.77 | ADH1B (0.54) | TSHRCYP2D6HIF1ACA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425638-B2 | Cis-imidazolines | HOFFMANN-LA ROCHE INC. (US) | 2008-09-16 | — | — | US | claimed |
| EP-1638942-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-29 | — | — | EP | claimed |
| WO-2005003097-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-13 | — | — | WO | claimed |
| US-20040259884-A1 | Cis-imidazolines | HALEY GREGORY JAY (US) | 2004-12-23 | — | — | US | claimed |
| US-5071735-A | SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL CONTAINING A COMPOUND RELEASING A DIR COMMAND UPON REACTION WITH AN OXIDIZED DEVELOPING AGENT | FUJI PHOTO FILM CO., LTD. (JP) | 1991-12-10 | — | — | US | claimed |
| EP-0362870-A2 | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1990-04-11 | — | — | EP | claimed |
| US-20080312242-A1 | 7-ARYL-3, 9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS, LTD. (CH) | 2008-12-18 | — | — | US | disclosed |
| US-7427613-B2 | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases | ACTELION PHARMACEUTICALS LTD. (CH) | 2008-09-23 | — | — | US | disclosed |
| US-7425638-B2 | Cis-imidazolines | HOFFMANN-LA ROCHE INC. (US) | 2008-09-16 | — | — | US | disclosed |
| EP-1638942-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-29 | — | — | EP | disclosed |
| US-20050176700-A1 | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases | ACTELION PHARMACEUTICALS LTD. (CH) | 2005-08-11 | — | — | US | disclosed |
| EP-1501830-A1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | Actelion Pharmaceuticals Ltd. (CH) | 2005-02-02 | — | — | EP | disclosed |
| WO-2005003097-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-13 | — | — | WO | disclosed |
| EP-0503658-A1 | Silver halide colour photographic light sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1992-09-16 | — | — | EP | disclosed |
| US-5071735-A | SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL CONTAINING A COMPOUND RELEASING A DIR COMMAND UPON REACTION WITH AN OXIDIZED DEVELOPING AGENT | FUJI PHOTO FILM CO., LTD. (JP) | 1991-12-10 | — | — | US | disclosed |
| EP-0362870-A2 | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1990-04-11 | — | — | EP | disclosed |
| US-4044153-A | ANTIEDEMIC | MERCK & CO., INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-4044153-A | ANTIEDEMIC | MERCK & CO., INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3979361-A | ANTIEDEMA, ANTIINFLAMMATORY | MERCK & CO., INC. (US) | 1976-09-07 | — | — | US | disclosed |
| US-3979361-A | ANTIEDEMA, ANTIINFLAMMATORY | MERCK & CO., INC. (US) | 1976-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259884-A1 | Cis-imidazolines | TP53, MDM2, TP53BP1 | TSHR 2923/4885CYP2D6 3283/4885HIF1A 2497/4885 |
| US-20050176700-A1 | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases | REN, AGTR1, ACE | TSHR 2730/4885CYP2D6 14/4885HIF1A 2021/4885 |
| US-20080312242-A1 | 7-ARYL-3, 9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | REN, AGTR1, ACE | TSHR 2730/4885CYP2D6 14/4885HIF1A 2021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.