SCHEMBL10281176

SCHEMBL10281176

Cn1c(-c2ccc(C(F)(F)F)cc2F)nc2cc(C(F)(F)F)cc(N)c21

nearest known ligand 0.47

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 2/20 0.47
MPL P40238 2/20 0.44
FEN1 P39748 4/20 0.39
PDE2A O00408 4/20 0.38
PDE10A Q9Y233 3/20 0.38
ALOX5AP P20292 3/20 0.38
CYP1A2 P05177 1/20 0.35
ILK Q13418 2/20 0.35
ALDH1A1 P00352 1/20 0.35
PKM P14618 1/20 0.35
BACE1 P56817 1/20 0.35
AGPAT2 O15120 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15426505 0.91 HSD11B1 (0.46) HSD11B1MPLFEN1PDE2APDE10A
SCHEMBL10281012 0.80 HSD11B1 (0.52) HSD11B1MPLPDE2APDE10ACYP1A2
SCHEMBL10280804 0.76 HSD11B1 (0.48) HSD11B1MPLFEN1PDE2APDE10A
SCHEMBL9953119 0.75 SLC6A2 (0.38) HSD11B1FEN1PDE2APDE10AALOX5AP
SCHEMBL15426497 0.74 HSD11B1 (0.49) HSD11B1MPLPDE2APDE10AAGPAT2
SCHEMBL16280605 0.73 HSD11B1 (0.48) HSD11B1MPLPDE2APDE10A
SCHEMBL16064958 0.72 HSD11B1 (0.50) HSD11B1MPLPDE2APDE10ACYP1A2
SCHEMBL15426486 0.72 HSD11B1 (0.47) HSD11B1MPLFEN1PDE2APDE10A
SCHEMBL167106 0.68 PDE10A (0.46) HSD11B1PDE2APDE10ACYP1A2AGPAT2
SCHEMBL10280803 0.68 POLB (0.43) HSD11B1PDE2APDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006429-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2019-02-06 EP disclosed
EP-2655337-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2016-11-23 EP disclosed
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed
WO-2012086848-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 HSD11B1 1704/4885MPL 4785/4885FEN1 3336/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 HSD11B1 1639/4885MPL 4784/4885FEN1 3449/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.