Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1911399 | 0.89 | EPHX2 (0.40) | USP30MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL89909 | 0.88 | PDE4B (0.36) | USP30MEN1KMT2AGPR119REN | |
| SCHEMBL89632 | 0.87 | PDE4B (0.39) | USP30MEN1KMT2ASCN9AGPR119 | |
| SCHEMBL1911384 | 0.87 | MEN1 (0.46) | USP30MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL89118 | 0.80 | REN (0.42) | USP30MEN1KMT2AMAPTREN | |
| SCHEMBL89756 | 0.78 | MEN1 (0.37) | USP30MEN1KMT2AGPR119REN | |
| SCHEMBL10283299 | 0.78 | REN (0.57) | REN | |
| SCHEMBL90536 | 0.77 | PDE4B (0.40) | USP30MEN1KMT2AGPR119REN | |
| SCHEMBL1911552 | 0.76 | REN (0.63) | MEN1KMT2AALDH1A1MAPTREN | |
| SCHEMBL89134 | 0.76 | GPR119 (0.37) | USP30MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |