Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 5/20 | 0.70 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.70 |
| ▸ | ALB | P02768 | 1/20 | 0.70 |
| ▸ | ESR1 | P03372 | 1/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.70 |
| ▸ | RARB | P10826 | 1/20 | 0.70 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.70 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.70 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3894104 | 1.00 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL1028462 | 1.00 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL9257901 | 0.83 | PTGS2 (0.46) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL19439560 | 0.82 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL3001 | 0.82 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL19439559 | 0.82 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Dexibuprofen SCHEMBL30091137 | 0.82 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL239446 | 0.82 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL8754799 | 0.82 | PTGS1 (1.00) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL4471196 | 0.82 | CXCR1 (0.79) | CXCR1CXCR2PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050154051-A1 | Method for the preparation of escitalopram | H. LUNDBECK A/S (DK) | 2005-07-14 | — | — | US | claimed |
| CN-1602305-A | Method for the preparation of escitalopram | LUNDBECK & CO AS H (DK) | 2005-03-30 | — | — | CN | claimed |
| EP-1458701-A1 | METHOD FOR THE PREPARATION OF ESCITALOPRAM | H. Lundbeck A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051861-A1 | METHOD FOR THE PREPARATION OF ESCITALOPRAM | H. LUNDBECK A/S (DK) | 2003-06-26 | — | — | WO | claimed |
| US-20250241922-A1 | ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF | COVAL BIOPHARMA (SHANGHAI)CO., LTD. (CN) | 2025-07-31 | — | — | US | disclosed |
| US-20250241921-A1 | ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF | COVAL BIOPHARMA (SHANGHAI)CO., LTD. (CN) | 2025-07-31 | — | — | US | disclosed |
| US-12290519-B2 | Anti-inflammatory coupling compound drug, and preparation method therefor and use thereof | COVAL BIOPHARMA (SHANGHAI) CO., LTD. (CN) | 2025-05-06 | — | — | US | disclosed |
| US-20240197741-A1 | EXTERNAL ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF | COVAL BIOPHARMA(SHANGHAI)CO., LTD. (CN) | 2024-06-20 | — | — | US | disclosed |
| CN-117355527-B | Anti-inflammatory coupling compound medicine and preparation method and application thereof | 上海椿安生物医药科技有限公司 | 2024-06-07 | — | — | CN | disclosed |
| EP-4357346-A1 | EXTERNAL ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Coval Biopharma (Shanghai) Co., Ltd. (CN) | 2024-04-24 | — | — | EP | disclosed |
| CN-117355527-A | External anti-inflammatory coupling compound medicine and preparation method and application thereof | 上海椿安生物医药科技有限公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-117105822-A | Synthesis method of (R) -3- (tertiary Ding Yangtan group) amino-2-methylpropanoic acid | 杭州澳赛诺生物科技有限公司 | 2023-11-24 | — | — | CN | disclosed |
| US-5191095-A | Preparation of ibuprofen | ETHYL CORPORATION (US) | 1993-03-02 | — | — | US | disclosed |
| WO-1992020334-A1 | PHARMACEUTICAL COMPOSITION COMPRISING IBUPROFEN SALT | THE BOOTS COMPANY PLC (GB) | 1992-11-26 | — | — | WO | disclosed |
| US-4840936-A | ANTIFLAMMATORY, ANALGESIC AGENT TO PREVENT ARRHYTHMIAS | ZAMBON S.P.A. (IT) | 1989-06-20 | — | — | US | disclosed |
| US-4812477-A | Thioesters for the treatment of ischemia and reperfusion syndromes | ZAMBON S.P.A. (IT) | 1989-03-14 | — | — | US | disclosed |
| US-4806567-A | Method for the treatment of ischemia and reperfusion syndromes | ZAMBON S.P.A. (IT) | 1989-02-21 | — | — | US | disclosed |
| EP-0255164-A2 | A thioester and its use for preparing pharmaceutical compositions for the treatment of ischemia and reperfusion syndromes | ZAMBON S.p.A. (IT) | 1988-02-03 | — | — | EP | disclosed |
| EP-0254354-A1 | Pharmaceutically useful derivatives of thiazolidine-4-carboxylic acid | ZAMBON S.p.A. (IT) | 1988-01-27 | — | — | EP | disclosed |
| US-4134989-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, ANTIPYRETIC, ANTISEPTIC, EXPECTORATING AGENTS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 1979-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250241921-A1 | ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF | JAK1, TNF, CYP4A11 | CXCR1 310/4885CXCR2 288/4885PTGS1 16/4885 |
| US-20050154051-A1 | Method for the preparation of escitalopram | SLC6A4, TPH2, SLC6A3 | CXCR1 2084/4885CXCR2 2896/4885PTGS1 2238/4885 |
| US-12290519-B2 | Anti-inflammatory coupling compound drug, and preparation method therefor and use thereof | JAK1, TNF, CYP4A11 | CXCR1 310/4885CXCR2 288/4885PTGS1 16/4885 |
| US-20250241922-A1 | ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF | JAK1, TNF, CYP4A11 | CXCR1 310/4885CXCR2 288/4885PTGS1 16/4885 |
| US-20240197741-A1 | EXTERNAL ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF | TNF, CYP4A11, JAK1 | CXCR1 824/4885CXCR2 691/4885PTGS1 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.