SCHEMBL102848

SCHEMBL102848

FC(F)(F)c1c[c]cc(C(F)(F)F)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.40
TSHR P16473 2/20 0.36
ALDH1A1 P00352 1/20 0.36
IDO1 P14902 2/20 0.36
MAPK1 P28482 1/20 0.33
ADRB1 P08588 1/20 0.32
HTR3E A5X5Y0 2/20 0.31
HTR3B O95264 2/20 0.31
HTR3A P46098 2/20 0.31
HTR3D Q70Z44 2/20 0.31
HTR3C Q8WXA8 2/20 0.31
MAPT P10636 1/20 0.31
RAPGEF4 Q8WZA2 1/20 0.31
ITGB3 P05106 1/20 0.31
ITGAV P06756 1/20 0.31
RXRA P19793 1/20 0.31
RXRB P28702 1/20 0.31
RXRG P48443 1/20 0.31
KIF11 P52732 2/20 0.31
PTPN5 P54829 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28642337 0.97 CES2 (0.39) CES2TSHRALDH1A1IDO1MAPK1
SCHEMBL23174652 0.97 CES2 (0.39) CES2TSHRALDH1A1IDO1MAPK1
SCHEMBL27886103 0.97 CES2 (0.39) CES2TSHRALDH1A1IDO1MAPK1
SCHEMBL29121446 0.97 CES2 (0.39) CES2TSHRALDH1A1IDO1MAPK1
SCHEMBL28585089 0.89 CES2 (0.34) CES2TSHRALDH1A1IDO1HTR3E
Magnesium Chloride Anhydrous SCHEMBL29163555 0.89 CES2 (0.34) CES2TSHRALDH1A1IDO1
SCHEMBL2879163 0.87 KIF11 (0.38) CES2IDO1MAPTRAPGEF4KIF11
SCHEMBL20526168 0.87 CES2 (0.33) CES2IDO1MAPTRAPGEF4KIF11
SCHEMBL596022 0.84 RAPGEF4 (0.35) CES2TSHRALDH1A1MAPTRAPGEF4
SCHEMBL147083 0.84 AHR (0.36) CES2TSHRALDH1A1MAPTRAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9647 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118344695-A Hydroxyl-enriched cycloolefin copolymer long afterglow material and application thereof 重庆理工大学 2024-07-16 CN claimed
CN-118344355-A Quinazolinone derivative, preparation method thereof and application thereof in anti-inflammatory and anti-tumor 贵州省天然产物研究中心 2024-07-16 CN claimed
US-20240217913-A2 PREPARATION OF SUBSTITUTED ACRYLATE COMPOUND HUA MEDICINE (SHANGHAI) LTD. (CN) 2024-07-04 US claimed
EP-4392419-A1 NOVEL PYRAZINYL-TRIAZOLE COMPOUNDS AS PESTICIDES Bayer Aktiengesellschaft (DE) 2024-07-03 EP claimed
CN-116178219-B Chiral diarylmethylamine compound and preparation method thereof 上海工程技术大学 2024-06-28 CN claimed
WO-2024132803-A1 FLUORESCENT PHENYL XANTHENE DYES BASF SE (DE) 2024-06-27 WO claimed
WO-2024132801-A1 XANTHENE COMPOUNDS HAVING A WAVELENGTH IN THE RANGE FROM 650 TO 1200 NM BASF SE (DE) 2024-06-27 WO claimed
US-20240196732-A1 ORGANIC ELECTRONIC DEVICE, DISPLAY DEVICE COMPRISING THE ORGANIC ELECTRONIC DEVICE AS WELL AS COMPOUNDS FOR USE IN ORGANIC ELECTRONIC DEVICES NOVALED GMBH (DE) 2024-06-13 US claimed
CN-118146274-A PNN tridentate ligand with face chirality and phosphine chirality and application thereof in free radical asymmetric functionalization and related reaction 武汉大学 2024-06-07 CN claimed
CN-118119596-A Preparation method of drug intermediate 浙江华海药业股份有限公司 2024-05-31 CN claimed
US-4378357-A FUNGICIDES ROHM AND HAAS COMPANY (US) 1983-03-29 US claimed
US-4366155-A 1-Benzoyl-3-(6-oxopyridazinyl)ureas, compositions, and insecticidal method ELI LILLY AND COMPANY (US) 1982-12-28 US claimed
EP-0063413-A1 1-Benzoyl-3-(heterocyclic)ureas, compositions, and insecticidal method ELI LILLY AND COMPANY (US) 1982-10-27 EP claimed
US-4264605-A INSECTICIDES ELI LILLY AND COMPANY (US) 1981-04-28 US claimed
EP-0026040-A1 Substituted benzophenone hydrazones, pesticidal compositions containing them and method of combating pests FBC LIMITED (GB) 1981-04-01 EP claimed
US-4230875-A Fungicidal, miticidal and ovicidal alkoxycarbonylalkyl-substituted and carbamylalkyl-substituted N-haloalkylthiosulfonamides CHEVRON RESEARCH COMPANY (US) 1980-10-28 US claimed
EP-0008881-A1 1-Benzoyl-3-pyridinyl ureas, their use as insecticides, their preparation and formulations containing them ELI LILLY AND COMPANY (US) 1980-03-19 EP claimed
US-4192873-A Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones CIBA-GEIGY CORPORATION (US) 1980-03-11 US claimed
US-4153617-A Anorexic chromans BEECHAM GROUP LIMITED (GB) 1979-05-08 US claimed
US-4073783-A PENICILLINS PFIZER INC. (US) 1978-02-14 US claimed