Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | ILK | Q13418 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | IGF1R | P08069 | 4/20 | 0.45 |
| ▸ | TEK | Q02763 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687314 | 0.83 | ILK (0.56) | ILKMAPTMEN1KMT2ANPC1 | |
| SCHEMBL686882 | 0.80 | ILK (0.45) | GSK3BILKMAPTMEN1KMT2A | |
| SCHEMBL715973 | 0.77 | ILK (0.54) | ILKMAPTMEN1KMT2ANPC1 | |
| SCHEMBL687108 | 0.77 | KDM4E (0.61) | ILKMAPTMEN1KMT2ANPC1 | |
| SCHEMBL24155566 | 0.76 | MAPT (0.57) | GSK3BMAPTMEN1KMT2ANPC1 | |
| SCHEMBL687432 | 0.76 | ILK (0.56) | ILKMAPTMEN1KMT2ANPC1 | |
| SCHEMBL687313 | 0.72 | ILK (0.56) | ILKMAPTMEN1KMT2ANPC1 | |
| SCHEMBL14195557 | 0.72 | APP (0.71) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL686607 | 0.72 | ILK (0.42) | ILKMAPTMEN1KMT2ANPC1 | |
| SCHEMBL6644807 | 0.70 | ALDH1A1 (0.50) | MAPTMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542997-B1 | PYRAZOLYLBENZOTHIAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | DERMIRA CANADA INC (CA) | 2012-02-29 | — | — | EP | disclosed |