Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 11/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.47 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL687108 | 0.82 | KDM4E (0.61) | ILKKDM4ENPC1RAB9AMAPT | |
| SCHEMBL687432 | 0.78 | ILK (0.56) | ILKKDM4ENPC1RAB9AMAPT | |
| SCHEMBL715973 | 0.77 | ILK (0.54) | ILKKDM4ENPC1RAB9AMAPT | |
| SCHEMBL687314 | 0.74 | ILK (0.56) | ILKKDM4ENPC1RAB9AMAPT | |
| SCHEMBL21779833 | 0.74 | KDM4E (0.63) | ILKKDM4ENPC1RAB9AMAPT | |
| SCHEMBL686476 | 0.72 | ILK (0.57) | ILKKDM4ENPC1RAB9AMAPT | |
| SCHEMBL686897 | 0.72 | KDM4E (0.64) | ILKKDM4ENPC1RAB9AMAPT | |
| SCHEMBL10285203 | 0.72 | GSK3B (0.58) | ILKKDM4ENPC1RAB9AMAPT | |
| SCHEMBL231307 | 0.72 | KDM4E (0.75) | ILKKDM4ENPC1RAB9AMAPT | |
| SCHEMBL15661858 | 0.72 | NPC1 (0.55) | ILKKDM4ENPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542997-B1 | PYRAZOLYLBENZOTHIAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | DERMIRA CANADA INC (CA) | 2012-02-29 | — | — | EP | disclosed |