Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | APP | P05067 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10285203 | 0.83 | GSK3B (0.58) | ILKKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL686882 | 0.82 | ILK (0.45) | ILKKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL687432 | 0.81 | ILK (0.56) | ILKKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL687108 | 0.79 | KDM4E (0.61) | ILKKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL715973 | 0.77 | ILK (0.54) | ILKKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL687313 | 0.74 | ILK (0.56) | ILKKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL10291165 | 0.74 | MAPT (0.63) | ILKKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL686607 | 0.74 | ILK (0.42) | ILKKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL687376 | 0.73 | KDM4E (0.68) | KDM4EMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL686516 | 0.73 | ALDH1A1 (0.61) | ILKKDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542997-B1 | PYRAZOLYLBENZOTHIAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | DERMIRA CANADA INC (CA) | 2012-02-29 | — | — | EP | disclosed |