Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033202 | 0.89 | KCNA5 (0.46) | KCNA5ALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL1028656 | 0.86 | SMN1; SMN2 (0.43) | KCNA5ALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL1032634 | 0.86 | ALDH1A1 (0.41) | KCNA5ALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL1031214 | 0.83 | KCNH2 (0.46) | ALDH1A1MAPK1LMNASMN1; SMN2MEN1 | |
| SCHEMBL1028175 | 0.81 | TP53 (0.52) | ALDH1A1LMNASMN1; SMN2TP53MEN1 | |
| SCHEMBL1029484 | 0.77 | HSD11B1 (0.47) | ALDH1A1L3MBTL1PKM | |
| SCHEMBL1031811 | 0.77 | HPGD (0.54) | ALDH1A1LMNASMN1; SMN2TP53MEN1 | |
| SCHEMBL13211936 | 0.75 | KCNA5 (0.59) | KCNA5ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1028167 | 0.75 | DRD4 (0.42) | KCNA5MAPK1LMNAMEN1KMT2A | |
| SCHEMBL1032620 | 0.75 | HTT (0.53) | ALDH1A1LMNASMN1; SMN2TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |