Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031902 | 0.86 | LMNA (0.45) | TP53POLBALDH1A1LMNAPKM | |
| SCHEMBL1032620 | 0.84 | HTT (0.53) | TP53POLBALDH1A1TSHRLMNA | |
| SCHEMBL1028177 | 0.84 | CNR2 (0.48) | TP53RAB9APOLBALDH1A1TSHR | |
| SCHEMBL1033202 | 0.84 | KCNA5 (0.46) | TP53POLBALDH1A1TSHRLMNA | |
| SCHEMBL1029484 | 0.83 | HSD11B1 (0.47) | ALDH1A1PKM | |
| SCHEMBL1031811 | 0.83 | HPGD (0.54) | TP53RAB9APOLBALDH1A1LMNA | |
| SCHEMBL1034078 | 0.82 | MAPT (0.46) | TP53POLBALDH1A1TSHRLMNA | |
| SCHEMBL1028655 | 0.81 | KCNA5 (0.44) | TP53ALDH1A1LMNAPKMSMN1; SMN2 | |
| SCHEMBL1030828 | 0.80 | MAPT (0.47) | RAB9APOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1032544 | 0.80 | MAPT (0.43) | TP53POLBALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |