Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GPER1 | Q99527 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | MGAM | O43451 | 3/20 | 0.45 |
| ▸ | SI | P14410 | 3/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10253049 | 0.83 | NPC1 (0.57) | NPC1RAB9ALMNASMN1; SMN2IDO1 | |
| SCHEMBL375488 | 0.79 | STAT3 (0.58) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL24073708 | 0.78 | KDR (0.64) | NPC1RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL8558332 | 0.75 | HSPA5 (0.71) | NPC1RAB9ALMNASMN1; SMN2IDO1 | |
| SCHEMBL29904487 | 0.75 | NPC1 (0.58) | NPC1RAB9ALMNASMN1; SMN2IDO1 | |
| SCHEMBL29904457 | 0.75 | HSPA5 (0.71) | NPC1RAB9ALMNASMN1; SMN2IDO1 | |
| SCHEMBL24073673 | 0.72 | KDM4E (0.58) | NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL19632762 | 0.72 | STAT3 (0.61) | NPC1RAB9ALMNASMN1; SMN2GAA | |
| SCHEMBL27135218 | 0.72 | CYP1A2 (0.55) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL27134415 | 0.72 | RAB9A (0.44) | NPC1RAB9ALMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010187-A1 | BROAD SPECTRUM BENZOTHIOPHENE-NITROTHIAZOLIDE AND OTHER ANTIMICROBIALS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010187-A1 | BROAD SPECTRUM BENZOTHIOPHENE-NITROTHIAZOLIDE AND OTHER ANTIMICROBIALS | NMT1, MLEC, EPN1 | NPC1 3834/4885RAB9A 3418/4885LMNA 3713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.