Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 1/20 | 0.71 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.71 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.71 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 8/20 | 0.59 |
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | METAP2 | P50579 | 1/20 | 0.55 |
| ▸ | METAP1 | P53582 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | SCD | O00767 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558332 | 1.00 | HSPA5 (0.71) | HSPA5HSPA8HSPA9HSPA2RAB9A | |
| SCHEMBL29176359 | 0.84 | RAB9A (0.60) | HSPA5HSPA8HSPA9HSPA2RAB9A | |
| SCHEMBL7946681 | 0.84 | RAB9A (0.56) | HSPA5HSPA8HSPA9HSPA2RAB9A | |
| SCHEMBL23804620 | 0.83 | HSPA5 (1.00) | HSPA5HSPA8HSPA9HSPA2SMN1; SMN2 | |
| SCHEMBL23804624 | 0.83 | HSPA5 (1.00) | HSPA5HSPA8HSPA9HSPA2SMN1; SMN2 | |
| SCHEMBL13212233 | 0.83 | ALDH1A1 (0.66) | MEN1KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL23818463 | 0.82 | HSPA5 (0.72) | HSPA5HSPA8HSPA9HSPA2RAB9A | |
| SCHEMBL6885830 | 0.81 | HSPA5 (0.58) | HSPA5HSPA8HSPA9HSPA2ALDH1A1 | |
| SCHEMBL29904487 | 0.79 | NPC1 (0.58) | HSPA5HSPA8HSPA9HSPA2RAB9A | |
| SCHEMBL31105660 | 0.79 | GLA (0.58) | HSPA5HSPA8HSPA9HSPA2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115785100-A | Compounds useful as RET inhibitors | 癌症研究科技有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-110506043-B | Compounds useful as RET inhibitors | 癌症研究科技有限公司 | 2022-11-01 | — | — | CN | disclosed |