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Sugi Predict / Targets / EPN1

EPN1

Epsin-1 · Q9Y6I3 · EPN1 on Sugi Atlas →

88 patent compounds predicted against EPN1, 75 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL70577 SCHEMBL70577 0.53 1/20
SCHEMBL18534204 SCHEMBL18534204 0.53 1/20
Water Water (SCHEMBL1267709) 0.52 1/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL7723258) 0.52 1/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL11595364) 0.52 1/20
SCHEMBL19987833 SCHEMBL19987833 0.52 1/20
SCHEMBL28638090 SCHEMBL28638090 0.52 1/20
SCHEMBL21810960 SCHEMBL21810960 0.50 1/20
Ammonia Solution, Strong Ammonia Solution, Strong (SCHEMBL28463590) 0.50 1/20
SCHEMBL5599765 SCHEMBL5599765 0.48 1/20
SCHEMBL12168148 SCHEMBL12168148 0.48 1/20
SCHEMBL1739326 SCHEMBL1739326 0.47 1/20
SCHEMBL2360520 SCHEMBL2360520 0.47 1/20
SCHEMBL2763093 SCHEMBL2763093 0.47 1/20
SCHEMBL4240356 SCHEMBL4240356 0.47 1/20
SCHEMBL5317023 SCHEMBL5317023 0.47 1/20
SCHEMBL6371053 SCHEMBL6371053 0.47 1/20
SCHEMBL10340622 SCHEMBL10340622 0.47 1/20
SCHEMBL27087481 SCHEMBL27087481 0.47 1/20
SCHEMBL30991131 SCHEMBL30991131 0.47 1/20

Clinical trials — most relevant to EPN1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pharmacogenomics of Antiplatelet Response - I PHASE4COMPLETED
Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and Safety PHASE2COMPLETED
Hereditary Sensory Neuropathy Serine Trial PHASE2UNKNOWN
Impact of Elastin Mediated Vascular Stiffness on End Organs nanCOMPLETED
Defining the Brain Phenotype of Children With Williams Syndrome nanRECRUITING
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants. nanUNKNOWN
Urine Concentration of S100B in Extremely Premature Infants nanCOMPLETED
Registry and Natural History Study for Progressive Myoclonus Epilepsy Type 1 (EPM1) nanRECRUITING
The Man Van Project nanRECRUITING
Epilepsy Phenome/Genome Project nanCOMPLETED
Intra-cortical Inhibition and Cognitive Deficits in Schizophrenia nanUNKNOWN
Human Epilepsy Genetics--Neuronal Migration Disorders Study nanRECRUITING
Familial Intracranial Aneurysm Study II nanCOMPLETED
Williams Syndrome (WS) and Supravalvar Aortic Stenosis (SVAS) DNA and Tissue Bank nanCOMPLETED
Family Heart Study - Subclinical Atherosclerosis Network (FHS-SCAN) nanCOMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation nanUNKNOWN
The Factors Associated With the Formation of Nasal polyp-a Case Control and Descriptive Study nanUNKNOWN
Genetic and Metabolic Disease in Children nanRECRUITING
Comparison of Two Methods to Diagnose Coronary Artery Disease nanCOMPLETED
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients nanNOT_YET_RECRUITING
Relationship of Gestational Age and Urine Concentration of S100B in Preterm and Term Infants in the First Week of Life nanCOMPLETED
Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations nanWITHDRAWN
Exploring the Genetics of Neuropathic Pain nanRECRUITING
Genetics and Psychopathology in the 22q11 Deletion Syndrome nanUNKNOWN
Endocan Levels in Women With Premature Ovarian Insufficiency nanCOMPLETED
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN) nanRECRUITING
Genetic and Non-Genetic Breast Cancer Risk Prediction Evaluation in Indonesian Samples nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a EPN1 binder may also engage these)

ProteinNameSimilarity
O88339 — 1.000 O88339 →
Q80VP1 — 1.000 Q80VP1 →
Q8CHU3 — 0.999 Q8CHU3 →
Q9Z1Z3 — 0.998 Q9Z1Z3 →
Q4V882 — 0.997 Q4V882 →
Q9H201 — 0.995 Q9H201 →
O95208 — 0.993 O95208 →
Q91W69 — 0.990 Q91W69 →
Q99KN9 — 0.989 Q99KN9 →
P42768 — 0.989 P42768 →
Q61548 — 0.988 Q61548 →
P50551 — 0.987 P50551 →
Q05140 — 0.987 Q05140 →
Q2TA49 — 0.987 Q2TA49 →
Q27974 — 0.986 Q27974 →
O60641 — 0.986 O60641 →
CLINT1 Clathrin interactor 1 0.986 landscape →
O75061 — 0.986 O75061 →
O95081 — 0.985 O95081 →
Q62219 — 0.985 Q62219 →
O43294 — 0.985 O43294 →
Q8L860 — 0.984 Q8L860 →
Q80WC7 — 0.984 Q80WC7 →
Q60902 — 0.984 Q60902 →
MAPK7 Mitogen-activated protein kinase 7 0.984 landscape →
Q63618 — 0.984 Q63618 →
Q8VD37 — 0.984 Q8VD37 →
O08719 — 0.984 O08719 →
Q29M42 — 0.983 Q29M42 →
A7Z035 — 0.983 A7Z035 →