Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29657985 | 0.82 | HPGDS (0.47) | HPGDSHCAR1CHEK2PARP1TRPV3 | |
| SCHEMBL22701135 | 0.82 | HPGDS (0.47) | HPGDSHCAR1CHEK2PARP1TRPV3 | |
| SCHEMBL742218 | 0.81 | HPGDS (0.52) | HPGDSJAK2JAK1GRIN2BHCAR1 | |
| SCHEMBL742219 | 0.81 | HPGDS (0.52) | HPGDSJAK2JAK1GRIN2BHCAR1 | |
| SCHEMBL16584386 | 0.81 | DGAT2 (0.57) | HPGDS | |
| SCHEMBL16584385 | 0.81 | DGAT2 (0.57) | HPGDS | |
| SCHEMBL16584388 | 0.81 | DGAT2 (0.57) | HPGDS | |
| SCHEMBL19408169 | 0.80 | HPGDS (0.57) | HPGDSPARP1CYP2C9PRMT5MAPK1 | |
| SCHEMBL739188 | 0.80 | HPGDS (0.57) | HPGDSPARP1CYP2C9PRMT5MAPK1 | |
| SCHEMBL762565 | 0.80 | HPGDS (0.57) | HPGDSPARP1CYP2C9PRMT5MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |