Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742218 | 1.00 | HPGDS (0.52) | HPGDSPARP1STSPRMT5JAK2 | |
| SCHEMBL762497 | 0.84 | PARP1 (0.52) | HPGDSPARP1PRMT5JAK2JAK1 | |
| SCHEMBL762565 | 0.83 | HPGDS (0.57) | HPGDSPARP1PRMT5KDM4E | |
| SCHEMBL19408169 | 0.83 | HPGDS (0.57) | HPGDSPARP1PRMT5KDM4E | |
| SCHEMBL739188 | 0.83 | HPGDS (0.57) | HPGDSPARP1PRMT5KDM4E | |
| SCHEMBL25363420 | 0.81 | HPGDS (0.57) | HPGDSPARP1PRMT5JAK2JAK1 | |
| SCHEMBL10292467 | 0.81 | HPGDS (0.50) | HPGDSPARP1PRMT5JAK2JAK1 | |
| SCHEMBL30496093 | 0.81 | HPGDS (0.57) | HPGDSPARP1PRMT5JAK2JAK1 | |
| SCHEMBL7892876 | 0.79 | STS (0.46) | HPGDSPARP1STSJAK2JAK1 | |
| SCHEMBL743450 | 0.77 | PTGS1 (0.57) | HPGDSPARP1PRMT5JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |