Dyrene

Dyrene

SCHEMBL1029356

COc1ccccc1O.Clc1nc(Cl)nc(Nc2ccccc2Cl)n1

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.65
ALDH1A1 P00352 2/20 0.65
KMT2A Q03164 2/20 0.65
KDM4E B2RXH2 1/20 0.65
SMN1; SMN2 Q16637 1/20 0.65
TSHR P16473 3/20 0.65
NPSR1 Q6W5P4 1/20 0.55
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
TP53 P04637 1/20 0.49
GAA P10253 1/20 0.47
LRRK2 Q5S007 1/20 0.45
PTK2 Q05397 1/20 0.44
HPGD P15428 2/20 0.43
THRB P10828 1/20 0.42
NPC1 O15118 3/20 0.42
RAB9A P51151 2/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
ATM Q13315 2/20 0.41
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dyrene SCHEMBL8178116 0.90 TSHR (0.75) MAPTALDH1A1KMT2AKDM4ESMN1; SMN2
Dyrene SCHEMBL7191646 0.87 MAPT (0.50) MAPTALDH1A1KMT2AKDM4ESMN1; SMN2
Dyrene SCHEMBL5483770 0.87 MAPT (0.50) MAPTALDH1A1KMT2AKDM4ESMN1; SMN2
Dyrene SCHEMBL21854003 0.85 TSHR (0.83) MAPTALDH1A1KMT2AKDM4ESMN1; SMN2
Dyrene SCHEMBL5954767 0.84 TSHR (0.86) MAPTALDH1A1KMT2AKDM4ESMN1; SMN2
Dyrene SCHEMBL504140 0.83 MAPT (0.46) MAPTALDH1A1KMT2AKDM4ESMN1; SMN2
Dyrene SCHEMBL1029941 0.83 MAPT (0.46) MAPTALDH1A1KMT2AKDM4ESMN1; SMN2
SCHEMBL29609022 0.82 MAPT (0.93) MAPTALDH1A1KMT2AKDM4ESMN1; SMN2
SCHEMBL6237782 0.82 MAPT (0.93) MAPTALDH1A1KMT2AKDM4ESMN1; SMN2
Dyrene SCHEMBL690206 0.82 TSHR (0.96) MAPTALDH1A1KMT2AKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102159181-A Cationic latex as a carrier for active ingredients and methods of making and using the same MALLAR CREEK POLYMERS INC 2011-08-17 CN claimed
EP-4216909-A1 MOISTURIZING ANTIBACTERIAL COMPOSITION Unilever IP Holdings B.V. (NL) 2023-08-02 EP disclosed
WO-2022063596-A1 MOISTURIZING ANTIBACTERIAL COMPOSITION UNILEVER IP HOLDINGS B.V. (NL) 2022-03-31 WO disclosed
US-11207256-B2 Method for solubilizing poorly water-soluble cosmetic agents ATHENION AG (CH) 2021-12-28 US disclosed
US-20200170915-A1 METHOD FOR SOLUBILIZING POORLY WATER-SOLUBLE COSMETIC AGENTS ATHENION AG (CH) 2020-06-04 US disclosed
EP-3645125-A1 METHOD FOR SOLUBILIZING POORLY WATER-SOLUBLE COSMETIC AGENTS Athenion AG (CH) 2020-05-06 EP disclosed
WO-2019001770-A1 METHOD FOR SOLUBILIZING POORLY WATER-SOLUBLE COSMETIC AGENTS ATHENION AG (CH) 2019-01-03 WO disclosed
EP-3421096-A1 METHOD FOR SOLUBILIZING POORLY WATER-SOLUBLE COSMETIC AGENTS Athenion AG (CH) 2019-01-02 EP disclosed
US-9333159-B2 Topical DNA repair composition PHOTOMEDEX, INC. (US) 2016-05-10 US disclosed
US-20150118272-A1 METHODS FOR ENHANCING COSMETIC OR DERMATOLOGICAL NOVEL COSMETIC OR DERMATOLOGICAL COMPOSITIONS CONTAINING A DIBENZOYL METHANE DERIVATIVE BY THE ADDITION OF MODIFIED TITANIUM DIOXIDE PARTICLES DSM IP ASSETS B.V. (NL) 2015-04-30 US disclosed
US-8278459-B2 UV-filter compounds DSM IP ASSETS B.V. (NL) 2012-10-02 US disclosed
CN-102421809-A Cationic comb copolymers, preparation thereof and use thereof in cosmetic, pharmaceutical and dermatological formulations CLARIANT INT LTD 2012-04-18 CN disclosed
EP-2274057-A1 SUNSCREENS DSM IP Assets B.V. (NL) 2011-01-19 EP disclosed
CN-101903005-A Cosmetic composition for imparting superhydrophobic film AVON PROD INC 2010-12-01 CN disclosed
US-20100119462-A1 UV-FILTER COMPOUNDS DSM IP ASSETS B.V. (NL) 2010-05-13 US disclosed
WO-2009138485-A1 SUNSCREENS DSM IP ASSETS B.V. (NL) 2009-11-19 WO disclosed
CN-101365412-A Novel cosmetic or dermatological combinations comprising modified titanium dioxide particles DSM IP ASSETS BV (NL) 2009-02-11 CN disclosed
US-20090016986-A1 Cosmetic Composition, a Pharmaceutical Composition and a Process for Preparing Said Compositions NATURA COSMETICOS S.A. (BR) 2009-01-15 US disclosed
US-20080305133-A1 Novel Cosmetic or Dermatological Combinations Comprising Modified Titanium Dioxide Particles DSM IP ASSETS B.V. (NL) 2008-12-11 US disclosed
US-7037515-B2 Anhydrous insect repellent composition AVON PRODUCTS INC. (US) 2006-05-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100119462-A1 UV-FILTER COMPOUNDS ERCC4, ERCC5, ERCC1 MAPT 1798/4885ALDH1A1 189/4885KMT2A 2742/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.