Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.93 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.93 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.93 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.93 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29609022 | 1.00 | MAPT (0.93) | MAPTALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL28939641 | 0.91 | MAPT (0.88) | MAPTALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| Dyrene SCHEMBL8178116 | 0.89 | TSHR (0.75) | MAPTALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL11813903 | 0.87 | MAPT (0.83) | MAPTALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| Dyrene SCHEMBL1029356 | 0.82 | MAPT (0.65) | MAPTALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL13326002 | 0.81 | MAPT (0.71) | MAPTALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL11837274 | 0.81 | TSHR (0.80) | MAPTALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| Dyrene SCHEMBL5954767 | 0.81 | TSHR (0.86) | MAPTALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL28176767 | 0.80 | MAPT (0.65) | MAPTALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL9697643 | 0.79 | MAPT (0.66) | MAPTALDH1A1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108191774-B | Heterocyclic compound, preparation method and application thereof | 中国药科大学 | 2022-05-24 | — | — | CN | disclosed |
| US-7718655-B2 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | NEW YORK UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718655-B2 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | NEW YORK UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| WO-2005011703-A1 | 2-CYANO-1,3,5-TRIAZINE-4,6-DIAMINE DERIVATIVES | AKZO NOBEL N.V. (NL) | 2005-02-10 | — | — | WO | disclosed |