Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.56 |
| ▸ | GRK2 | P25098 | 7/20 | 0.56 |
| ▸ | PRKCA | P17252 | 1/20 | 0.56 |
| ▸ | GRK5 | P34947 | 1/20 | 0.56 |
| ▸ | GRK3 | P35626 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294658 | 0.88 | MEN1 (0.54) | LMNAMAPK1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL13001971 | 0.85 | HDAC6 (0.66) | HDAC8HDAC6HDAC2LMNAMAPK1 | |
| SCHEMBL13702290 | 0.85 | HDAC6 (0.74) | HDAC8HDAC6HDAC2ALDH1A1GAA | |
| SCHEMBL10294885 | 0.85 | SMN1; SMN2 (0.51) | HDAC8LMNAALDH1A1GAAHSD17B10 | |
| SCHEMBL11900328 | 0.83 | HDAC6 (0.87) | HDAC8HDAC6HDAC2ALDH1A1GAA | |
| SCHEMBL1696365 | 0.82 | HDAC6 (0.66) | HDAC8HDAC6HDAC2ALDH1A1GAA | |
| SCHEMBL16598155 | 0.82 | HDAC6 (0.66) | HDAC8HDAC6HDAC2LMNAMAPK1 | |
| SCHEMBL27952268 | 0.82 | LMNA (0.70) | HDAC8HDAC6HDAC2LMNAMAPK1 | |
| SCHEMBL14044800 | 0.82 | HDAC2 (0.69) | HDAC8HDAC6HDAC2ALDH1A1GAA | |
| SCHEMBL10294868 | 0.81 | L3MBTL1 (0.65) | HDAC8LMNAALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CALIFORNIA CAPITAL EQUITY, LLC (US) | 2012-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172361-A1 | TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CYP3A5, CYP11B2, ABCB1 | HDAC8 390/4885HDAC6 18/4885HDAC2 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.