SCHEMBL10299249

SCHEMBL10299249

CC(C)N1C(=O)CC(C)(C)CC1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
POLB P06746 1/20 0.36
PTGES O14684 1/20 0.35
ALOX5 P09917 1/20 0.35
MAPT P10636 3/20 0.34
PKM P14618 1/20 0.34
ALDH1A1 P00352 3/20 0.33
RARA P10276 2/20 0.33
RARB P10826 2/20 0.33
RARG P13631 2/20 0.33
HTR1A P08908 1/20 0.33
DRD2 P14416 1/20 0.33
HTR2C P28335 1/20 0.33
HTR7 P34969 1/20 0.33
HRH1 P35367 1/20 0.33
HTR2B P41595 1/20 0.33
MAOA P21397 1/20 0.32
HPGD P15428 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21361741 0.78 MAPT (0.34) MEN1KMT2APOLBMAPTPKM
SCHEMBL13684330 0.78 KDM4E (0.48) KMT2ARARARARBRARGHTR1A
SCHEMBL11912105 0.76 RARA (0.40) MEN1KMT2AALDH1A1RARARARB
SCHEMBL12308312 0.75 SMN1; SMN2 (0.43) HTR1ADRD2
SCHEMBL10299246 0.75 HTR1A (0.40) ALDH1A1HTR1ADRD2HPGDNPSR1
SCHEMBL1514142 0.73 MEN1 (0.38) MEN1KMT2APOLBPTGESALOX5
SCHEMBL13199770 0.73 RARA (0.31) RARARARBRARG
SCHEMBL6956406 0.73
SCHEMBL1698550 0.73 SMN1; SMN2 (0.41) MEN1KMT2AMAPTPKMALDH1A1
SCHEMBL16472357 0.71 MAPT (0.34) MEN1KMT2APOLBMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10840397-B2 Highly-fluorescent and photo-stable chromophores for wavelength conversion NITTO DENKO CORPORATION (JP) 2020-11-17 US disclosed
US-20190284471-A1 WAVELENGTH CONVERSION FILMS WITH MULTIPLE PHOTOSTABLE ORGANIC CHROMOPHORES CHOSHU INDUSTRY CO., LTD. (JP) 2019-09-19 US disclosed
US-20180193330-A1 ALKYLATED TETRAHYDROISOQUINOLINES FOR BINDING TO CENTRAL NERVOUS SYSTEM RECEPTORS FLORIDA A&M UNIVERSITY 2018-07-12 US disclosed
US-20180193330-A1 ALKYLATED TETRAHYDROISOQUINOLINES FOR BINDING TO CENTRAL NERVOUS SYSTEM RECEPTORS FLORIDA A&M UNIVERSITY 2018-07-12 US disclosed
US-9960294-B2 Highly fluorescent and photo-stable chromophores for wavelength conversion NITTO DENKO CORPORATION (JP) 2018-05-01 US disclosed
US-9960294-B2 Highly fluorescent and photo-stable chromophores for wavelength conversion NITTO DENKO CORPORATION (JP) 2018-05-01 US disclosed
EP-2941474-B1 HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION NITTO DENKO CORP (JP) 2018-02-28 EP disclosed
US-20160108310-A1 WAVELENGTH CONVERSION FILMS WITH MULTIPLE PHOTOSTABLE ORGANIC CHROMOPHORES NITTO DENKO CORPORATION (JP) 2016-04-21 US disclosed
US-9221765-B2 Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives NORTH CAROLINA STATE UNIVERSITY (US) 2015-12-29 US disclosed
US-20150340519-A1 HIGHLY-FLUORESCENT AND PHOTO-STABLE CHROMOPHORES FOR WAVELENGTH CONVERSION NITTO DENKO CORPORATION (JP) 2015-11-26 US disclosed
US-20120171129-A1 Inhibition and Dispersion of Bacterial Biofilms with Benzimidazole Derivatives NORTH CAROLINA STATE UNIVERSITY 2012-07-05 US disclosed
US-7592419-B2 Macrocyclic inhibitors of hepatitis C virus NS3-serine protease SCHERING CORPORATION (US) 2009-09-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180193330-A1 ALKYLATED TETRAHYDROISOQUINOLINES FOR BINDING TO CENTRAL NERVOUS SYSTEM RECEPTORS NTSR2, HTR3B, NTSR1 MEN1 1725/4885KMT2A 2709/4885POLB 4776/4885
US-20120171129-A1 Inhibition and Dispersion of Bacterial Biofilms with Benzimidazole Derivatives SBDS, DBI, BRI3BP MEN1 4397/4885KMT2A 2548/4885POLB 462/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.