Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28169793 | 0.94 | KEAP1 (0.52) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL11334002 | 0.88 | KEAP1 (0.41) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL1033434 | 0.87 | KEAP1 (0.54) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL8997786 | 0.87 | KEAP1 (0.46) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL154374 | 0.86 | ALDH1A1 (0.46) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL28930621 | 0.85 | TSHR (0.44) | KEAP1SMN1; SMN2ALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL9434876 | 0.84 | ALOX15 (0.50) | SMN1; SMN2ALDH1A1ALOX15KDM4ECHRM2 | |
| SCHEMBL27699518 | 0.84 | — | — | |
| SCHEMBL22997580 | 0.83 | KEAP1 (0.50) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL8997666 | 0.83 | KEAP1 (0.41) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080103222-A1 | New Class of Amine Coinitiators in Photoinitiated Polymerizations | ALBEMARLE CORPORATION (US) | 2008-05-01 | — | — | US | claimed |
| US-20050197420-A1 | Class of amine coinitiators in photoinitiated polymerizations | ALBEMARLE CORPORATION | 2005-09-08 | — | — | US | claimed |
| EP-0078478-B1 | HIGH-FREQUENCY WELDABLE POLYURETHANE FOAMS, AND PROCESS FOR PREPARING THE SAME | BAYER AG (DE) | 1986-05-21 | — | — | EP | claimed |
| EP-4214256-B1 | LOW FREE POLYURETHANE PREPOLYMER COMPOSITION FOR REACTIVE HOT MELT ADHESIVES | LANXESS CORP (US) | 2024-09-11 | — | — | EP | disclosed |
| US-20230383157-A1 | LOW FREE POLYURETHANE PREPOLYMER COMPOSITION FOR REACTIVE HOT MELT ADHESIVES | LANXESS CORPORATION (US) | 2023-11-30 | — | — | US | disclosed |
| EP-4214256-A1 | LOW FREE POLYURETHANE PREPOLYMER COMPOSITION FOR REACTIVE HOT MELT ADHESIVES | LANXESS Corporation (US) | 2023-07-26 | — | — | EP | disclosed |
| US-20230203018-A1 | COVALENT INHIBITORS OF KRAS | ARAXES PHARMA LLC (US) | 2023-06-29 | — | — | US | disclosed |
| CN-116194505-A | Low free polyurethane prepolymer composition for reactive hot melt adhesives | 朗盛公司 | 2023-05-30 | — | — | CN | disclosed |
| WO-2022093817-A1 | MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS, AND METHODS OF MAKING AND USING SAME | YALE UNIVERSITY (US) | 2022-05-05 | — | — | WO | disclosed |
| WO-2022061087-A1 | LOW FREE POLYURETHANE PREPOLYMER COMPOSITION FOR REACTIVE HOT MELT ADHESIVES | LANXESS CORPORATION (US) | 2022-03-24 | — | — | WO | disclosed |
| EP-3267794-B1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2020-09-09 | — | — | EP | disclosed |
| EP-0054219-B1 | PROCESS FOR THE PRODUCTION OF FOAMED POLYURETHANES | BAYER AG (DE) | 1986-02-26 | — | — | EP | disclosed |
| EP-0172379-A1 | Material for orthopaedic bandages | BAYER AG (DE) | 1986-02-26 | — | — | EP | disclosed |
| EP-0132675-A2 | Preparations of polyisocynate containing reversibly blocked catalysts, process for their production, their use in the production of polyurethanes, and addition products of sulfonylisocyanates on catalysts with a structure of carboxylates of tin II or IV | BAYER AG (DE) | 1985-02-13 | — | — | EP | disclosed |
| US-4430453-A | USING AMMONIUM SALTS OF PHOSPHORUS CONTAINING ACIDS AS ADDITIVE | BAYER AKTIENGESELLSCHAFT (DE) | 1984-02-07 | — | — | US | disclosed |
| EP-0078478-A1 | High-frequency weldable polyurethane foams, and process for preparing the same | BAYER AG (DE) | 1983-05-11 | — | — | EP | disclosed |
| US-4379861-A | Process for the production of polyurethanes using morpholine compounds as catalysts | BAYER AKTIENGESELLSCHAFT (DE) | 1983-04-12 | — | — | US | disclosed |
| EP-0054219-A1 | Process for the production of foamed polyurethanes | BAYER AG (DE) | 1982-06-23 | — | — | EP | disclosed |
| US-4200575-A | 7[(2-Thiazolyl)-2-(oxoimino)acetamido]cephalosporin derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-04-29 | — | — | US | disclosed |
| EP-0000468-A1 | Polyols containing chlorine and ester groups and based on tetrachlorophtalic acid, their preparation and use for the preparation of flame retardant polyurethane or polyisocyanate foams | BASF Aktiengesellschaft (DE) | 1979-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203018-A1 | COVALENT INHIBITORS OF KRAS | KRAS, NRAS, HRAS | KEAP1 457/4885SMN1; SMN2 2227/4885HPGD 2493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.