Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18024015 | 0.91 | ALDH1A1 (0.50) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL18024079 | 0.91 | ALDH1A1 (0.50) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL12250550 | 0.90 | KEAP1 (0.48) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL21119152 | 0.89 | ALDH1A1 (0.47) | KEAP1SMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL20332973 | 0.88 | TDP1 (0.44) | KEAP1SMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL17346186 | 0.88 | KEAP1 (0.43) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL20333223 | 0.88 | TDP1 (0.44) | KEAP1SMN1; SMN2ALDH1A1POLBLMNA | |
| SCHEMBL1030003 | 0.87 | KEAP1 (0.54) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 | |
| SCHEMBL791912 | 0.86 | ALDH1A1 (0.46) | KEAP1SMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL23568468 | 0.85 | KEAP1 (0.44) | KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4214256-B1 | LOW FREE POLYURETHANE PREPOLYMER COMPOSITION FOR REACTIVE HOT MELT ADHESIVES | LANXESS CORP (US) | 2024-09-11 | — | — | EP | disclosed |
| US-20230399303-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | UNIV YALE (US) | 2023-12-14 | — | — | US | disclosed |
| US-20230383157-A1 | LOW FREE POLYURETHANE PREPOLYMER COMPOSITION FOR REACTIVE HOT MELT ADHESIVES | LANXESS CORPORATION (US) | 2023-11-30 | — | — | US | disclosed |
| EP-4214256-A1 | LOW FREE POLYURETHANE PREPOLYMER COMPOSITION FOR REACTIVE HOT MELT ADHESIVES | LANXESS Corporation (US) | 2023-07-26 | — | — | EP | disclosed |
| WO-2022093817-A1 | MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS, AND METHODS OF MAKING AND USING SAME | YALE UNIVERSITY (US) | 2022-05-05 | — | — | WO | disclosed |
| WO-2022061087-A1 | LOW FREE POLYURETHANE PREPOLYMER COMPOSITION FOR REACTIVE HOT MELT ADHESIVES | LANXESS CORPORATION (US) | 2022-03-24 | — | — | WO | disclosed |
| US-10968198-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2021-04-06 | — | — | US | disclosed |
| US-10925881-B2 | Treatment of conditions associated with hyperinsulinaemia | TENSHA THERAPEUTICS, INC. (US) | 2021-02-23 | — | — | US | disclosed |
| EP-3267794-B1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2020-09-09 | — | — | EP | disclosed |
| US-10676484-B2 | Compositions and methods for treating leukemia | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-06-09 | — | — | US | disclosed |
| EP-1341863-A2 | UV-RESISTANT FLOCKING ADHESIVE FOR POLYMER SUBSTRATES | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-09-10 | — | — | EP | disclosed |
| US-20030144454-A1 | Polyurethane compositions based on polyester block copolymers | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2003-07-31 | — | — | US | disclosed |
| WO-2003055929-A1 | REACTIVE POLYURETHANES HAVING A LOW CONTENT OF MONOMERIC DIISOCYANATES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-07-10 | — | — | WO | disclosed |
| US-20030045636-A1 | Polyurethane compositions on the basis of polyester-polyether copolymers | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2003-03-06 | — | — | US | disclosed |
| WO-2003006521-A1 | REACTIVE POLYURETHANES HAVING A REDUCED DIISOCYANATE MONOMERS CONTENT | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-01-23 | — | — | WO | disclosed |
| WO-2003002683-A1 | ADHESIVE/ WATERTIGHT MATERIAL WITH HIGH ELECTRICAL RESISTANCE | HENKEL TEROSON GMBH (DE) | 2003-01-09 | — | — | WO | disclosed |
| WO-2002038693-A2 | UV-RESISTANT FLOCKING ADHESIVE FOR POLYMER SUBSTRATES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2002-05-16 | — | — | WO | disclosed |
| EP-0054219-B1 | PROCESS FOR THE PRODUCTION OF FOAMED POLYURETHANES | BAYER AG (DE) | 1986-02-26 | — | — | EP | disclosed |
| US-4379861-A | Process for the production of polyurethanes using morpholine compounds as catalysts | BAYER AKTIENGESELLSCHAFT (DE) | 1983-04-12 | — | — | US | disclosed |
| EP-0054219-A1 | Process for the production of foamed polyurethanes | BAYER AG (DE) | 1982-06-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968198-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | MIF, MMP12, CSF1R | KEAP1 3766/4885SMN1; SMN2 4652/4885HPGD 2926/4885 |
| US-10676484-B2 | Compositions and methods for treating leukemia | MCL1, ABL1, FLT3 | KEAP1 2156/4885SMN1; SMN2 2078/4885HPGD 1604/4885 |
| US-10925881-B2 | Treatment of conditions associated with hyperinsulinaemia | GPR119, IAPP, SLC5A2 | KEAP1 2527/4885SMN1; SMN2 1509/4885HPGD 1253/4885 |
| US-20230399303-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | MIF, MMP12, METAP1 | KEAP1 1194/4885SMN1; SMN2 3388/4885HPGD 1425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.