Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | DRD2 | P14416 | 3/20 | 0.65 |
| ▸ | DRD1 | P21728 | 3/20 | 0.65 |
| ▸ | DRD4 | P21917 | 3/20 | 0.65 |
| ▸ | DRD5 | P21918 | 3/20 | 0.65 |
| ▸ | DRD3 | P35462 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.65 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.59 |
| ▸ | IGF1R | P08069 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13886168 | 0.90 | DRD1 (0.59) | HIF1AHSD17B10DRD2DRD1DRD4 | |
| SCHEMBL10876030 | 0.89 | HSD17B10 (0.63) | HIF1AHSD17B10DRD2DRD1DRD4 | |
| Hydrochloric Acid SCHEMBL10877816 | 0.88 | DRD2 (0.61) | HIF1AHSD17B10DRD2DRD1DRD4 | |
| SCHEMBL67764 | 0.88 | HIF1A (0.65) | HIF1AHSD17B10DRD2DRD1DRD4 | |
| SCHEMBL30141595 | 0.88 | HIF1A (0.65) | HIF1AHSD17B10DRD2DRD1DRD4 | |
| SCHEMBL14301921 | 0.87 | IGF1R (0.56) | HIF1AHSD17B10DRD2DRD1DRD4 | |
| Bromide SCHEMBL20854749 | 0.86 | KDM4E (0.66) | HIF1AHSD17B10DRD2DRD1DRD4 | |
| SCHEMBL7544044 | 0.84 | IGF1R (0.57) | HIF1AHSD17B10DRD2DRD1DRD4 | |
| SCHEMBL16449326 | 0.84 | DRD2 (0.61) | HIF1AHSD17B10DRD2DRD1DRD4 | |
| SCHEMBL7319293 | 0.84 | HIF1A (0.61) | HIF1AHSD17B10DRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156772-B2 | Fluoride-releasing compositions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-13 | — | — | US | disclosed |
| US-20140088308-A1 | Fluoride-Releasing Compositions | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2014-03-27 | — | — | US | disclosed |
| US-20120264939-A1 | Fluoride-Releasing Compositions | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-10-18 | — | — | US | disclosed |
| US-8217173-B2 | Fluoride-releasing compositions | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2012-07-10 | — | — | US | disclosed |
| US-20100261902-A1 | Fluoride-Releasing Compositions | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY (US) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088308-A1 | Fluoride-Releasing Compositions | CHERP, ORAI1, CAD | HIF1A 2166/4885HSD17B10 4626/4885DRD2 3035/4885 |
| US-20120264939-A1 | Fluoride-Releasing Compositions | CHERP, ORAI1, CAD | HIF1A 2166/4885HSD17B10 4626/4885DRD2 3035/4885 |
| US-20100261902-A1 | Fluoride-Releasing Compositions | CHERP, ORAI1, CAD | HIF1A 2166/4885HSD17B10 4626/4885DRD2 3035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.