SCHEMBL1030697

SCHEMBL1030697

CC(C)Cc1c(C=O)sc2cc(C(F)(F)F)ccc12

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 1/20 0.34
PTGER3 P43115 1/20 0.34
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
DYRK1A Q13627 1/20 0.32
EPHX2 P34913 1/20 0.32
SCN4A P35499 1/20 0.32
CSNK1D P48730 1/20 0.32
HRH4 Q9H3N8 1/20 0.31
MAPT P10636 1/20 0.31
KIF11 P52732 1/20 0.31
TP53 P04637 1/20 0.31
TSHR P16473 1/20 0.31
PPARA Q07869 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
PDE2A O00408 2/20 0.30
AAK1 Q2M2I8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1034046 0.83 GSK3B (0.33) DYRK1AEPHX2SCN4ACSNK1DHRH4
SCHEMBL1034624 0.81 RORA (0.34) DYRK1AEPHX2SCN4ACSNK1DHRH4
SCHEMBL1034047 0.80 KIF11 (0.36) DYRK1AEPHX2SCN4AHRH4MAPT
SCHEMBL718341 0.77 MEN1 (0.39) DYRK1AEPHX2SCN4ACSNK1DHRH4
SCHEMBL27808932 0.77 HRH4 (0.34) PTGER1PTGER3HTR2AHTR2CHTR2B
SCHEMBL1035129 0.77 PTGER1 (0.35) PTGER1PTGER3HTR2AHTR2CHTR2B
SCHEMBL27829371 0.76 AKR1B1 (0.41) PTGER1PTGER3CSNK1DPPARA
SCHEMBL1030581 0.75 ALDH1A1 (0.43) PTGER1PTGER3DYRK1ACSNK1DMAPT
SCHEMBL27829370 0.75 ALDH1A1 (0.40) PTGER1PTGER3DYRK1ACSNK1DKIF11
SCHEMBL719414 0.69 MEN1 (0.42) DYRK1AEPHX2SCN4AMAPTKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3424917-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2019-01-09 EP disclosed
EP-2277874-B1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR NIPPON CHEMIPHAR CO (JP) 2018-06-27 EP disclosed
CN-104672220-A Activating agent for peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO 2015-06-03 CN disclosed
CN-102083810-B Activator of peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO.,LTD. (JP) 2014-10-29 CN disclosed
US-8648208-B2 Activating agent for peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO. LTD. (JP) 2014-02-11 US disclosed
CN-102083810-A Activator of peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO 2011-06-01 CN disclosed
US-20110098480-A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR NIPPON CHEMIPHAR CO. LTD. (JP) 2011-04-28 US disclosed
EP-2277874-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2011-01-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110098480-A1 ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR PPARA, PPARG, PPARD PTGER1 144/4885PTGER3 521/4885HTR2A 3404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.