Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | ADH1B | P00325 | 1/20 | 0.32 |
| ▸ | ADH1C | P00326 | 1/20 | 0.32 |
| ▸ | ADH1A | P07327 | 1/20 | 0.32 |
| ▸ | ADH4 | P08319 | 1/20 | 0.32 |
| ▸ | ADH7 | P40394 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600712 | 0.79 | GPR35 (0.33) | GPR35 | |
| SCHEMBL16901812 | 0.70 | GPR35 (0.40) | GPR35TSHRHIF1AEPAS1 | |
| SCHEMBL1164646 | 0.69 | GPR35 (0.43) | GPR35HIF1ALMNA | |
| SCHEMBL17056920 | 0.69 | GPR35 (0.38) | GPR35HIF1AEPAS1 | |
| SCHEMBL2754793 | 0.69 | GPR35 (0.36) | GPR35HIF1AEPAS1 | |
| SCHEMBL12374319 | 0.67 | GSK3B (0.56) | GPR35CA2GSK3B | |
| SCHEMBL31513841 | 0.66 | HIF1A (0.37) | GPR35TSHRHIF1AEPAS1 | |
| SCHEMBL21721280 | 0.64 | GPR35 (0.33) | GPR35 | |
| Nonane SCHEMBL29223324 | 0.59 | TSHR (0.61) | TSHREPHX1ADH1BADH1CADH1A | |
| Nonane SCHEMBL4543993 | 0.59 | TSHR (0.61) | TSHREPHX1ADH1BADH1CADH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274310-B1 | FUSED THIOPHENES AND METHODS FOR MAKING AND USING SAME | CORNING INC (US) | 2016-05-25 | — | — | EP | disclosed |
| US-8575354-B1 | Fused thiophenes and methods for making and using same | CORNING INCORPORATED (US) | 2013-11-05 | — | — | US | disclosed |
| US-20130281707-A1 | FUSED THIOPHENES AND METHODS FOR MAKING AND USING SAME | CORNING INC (US) | 2013-10-24 | — | — | US | disclosed |
| US-8487114-B2 | Fused thiophenes and methods for making and using same | CORNING INCORPORATED (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110098478-A1 | FUSED THIOPHENES AND METHODS FOR MAKING AND USING SAME | CORNING INCORPORATED | 2011-04-28 | — | — | US | disclosed |
| EP-2274310-A1 | FUSED THIOPHENES AND METHODS FOR MAKING AND USING SAME | Corning Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009123695-A1 | FUSED THIOPHENES AND METHODS FOR MAKING AND USING SAME | CORNING INCORPORATED (US) | 2009-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098478-A1 | FUSED THIOPHENES AND METHODS FOR MAKING AND USING SAME | TST, TPST2, STS | GPR35 4222/4885TSHR 815/4885HIF1A 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.