Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.48 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.48 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.48 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.48 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.48 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.70 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 7/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | HRH2 | P25021 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030772 | 0.99 | PDK1 (0.71) | PDK1LIMK1DRD3DRD2HRH2 | |
| SCHEMBL1700743 | 0.85 | PDK1 (0.74) | PDK1LIMK1LMNAGAAMAPT | |
| SCHEMBL9874973 | 0.85 | PDK1 (0.52) | PDK1DRD3DRD2HRH2ADRA2A | |
| SCHEMBL17385025 | 0.84 | PDK1 (0.73) | PDK1LIMK1LMNAPOLBGAA | |
| SCHEMBL22677886 | 0.83 | PDK1 (0.71) | PDK1LIMK1LMNAGAAMAPT | |
| SCHEMBL12680627 | 0.81 | PDK1 (0.68) | PDK1LIMK1POLBGAAMAPT | |
| SCHEMBL406838 | 0.81 | PDK1 (0.68) | PDK1LIMK1LMNAGAAMAPT | |
| SCHEMBL3537067 | 0.81 | PDK1 (0.64) | PDK1LIMK1DRD3DRD2HRH2 | |
| Bromide SCHEMBL3055052 | 0.81 | PDK1 (0.64) | PDK1LIMK1LMNAPOLBMAPT | |
| Bromide SCHEMBL1031876 | 0.80 | PDK1 (0.60) | PDK1LIMK1LMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120253047-A1 | PROCESS FOR THE PREPARATION OF (R)-PRAMIPEXOLE | DIPHARMA S.P.A. (IT) | 2012-10-04 | — | — | US | disclosed |
| US-8203002-B2 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2012-06-19 | — | — | US | disclosed |
| EP-2289885-A1 | Intermediates for the preparation of pramipexole | Dipharma Francis S.r.l. (IT) | 2011-03-02 | — | — | EP | disclosed |
| EP-1730129-B1 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | DIPHARMA FRANCIS SRL (IT) | 2011-01-19 | — | — | EP | disclosed |
| US-20100222595-A1 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | DIPHARMA S.P.A. (IT) | 2010-09-02 | — | — | US | disclosed |
| US-7741490-B2 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2010-06-22 | — | — | US | disclosed |
| US-20070191439-A1 | Intermediates for the preparation of pramipexole | DIPHARMA S.P.A. (IT) | 2007-08-16 | — | — | US | disclosed |
| EP-1730129-A2 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | Dipharma S.p.A. (IT) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005092871-A2 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | DIPHARMA S.P.A. (IT) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222595-A1 | INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOLE | CYP11B2, CYP11B1, CYP4A11 | ADRA2A 217/4885ADRB2 175/4885HTR1A 256/4885 |
| US-20120253047-A1 | PROCESS FOR THE PREPARATION OF (R)-PRAMIPEXOLE | DPP4, DNPEP, PNMT | ADRA2A 82/4885ADRB2 49/4885HTR1A 104/4885 |
| US-20070191439-A1 | Intermediates for the preparation of pramipexole | CYP11B2, CYP11B1, CYP4A11 | ADRA2A 217/4885ADRB2 175/4885HTR1A 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.