Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28948998 | 0.92 | MEN1 (0.52) | ALDH1A1MEN1KMT2APPARDTHRB | |
| SCHEMBL28948999 | 0.92 | MEN1 (0.52) | ALDH1A1MEN1KMT2APPARDTHRB | |
| SCHEMBL10308499 | 0.92 | MEN1 (0.52) | ALDH1A1MEN1KMT2APPARDTHRB | |
| SCHEMBL10158983 | 0.87 | PPARD (0.48) | ALDH1A1PPARDTSHRPKMTP53 | |
| SCHEMBL14570488 | 0.86 | MEN1 (0.46) | ALDH1A1MEN1KMT2APPARDTHRB | |
| SCHEMBL14582791 | 0.86 | MEN1 (0.46) | ALDH1A1MEN1KMT2APPARDTHRB | |
| SCHEMBL14582788 | 0.83 | TSHR (0.47) | ALDH1A1MEN1KMT2APPARDTSHR | |
| SCHEMBL12116723 | 0.83 | TSHR (0.42) | ALDH1A1PPARDTSHRCYP3A4PKM | |
| SCHEMBL10416347 | 0.82 | TSHR (0.55) | ALDH1A1MEN1KMT2APPARDTHRB | |
| SCHEMBL21694823 | 0.80 | PPARD (0.45) | ALDH1A1MEN1KMT2APPARDTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9024014-B2 | Phosphorus-containing compounds and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-9024014-B2 | Phosphorus-containing compounds and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-20120178714-A1 | Phosphorus-containing Compounds & Uses Thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2012-07-12 | — | — | US | disclosed |
| US-8058426-B2 | Phosphorus-containing compounds and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-20100197907-A1 | Phosphorus-containing compounds & uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2010-08-05 | — | — | US | disclosed |
| US-7709020-B2 | Rapamaycin derivatives used as fungicides, anticarcinogenic agents, immunosuppressants or as coatings on drug eluting stents to prevent restenosis | ARIAD PHARMACEUTICALS, INC. (US) | 2010-05-04 | — | — | US | disclosed |
| US-20070190106-A1 | Phosphorus-containing compounds & uses thereof | MEDINOL LTD. (IL) | 2007-08-16 | — | — | US | disclosed |
| US-7186826-B2 | Phosphorus-containing compounds and uses thereof | ARIAD GENE THERAPEUTICS, INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-20070026434-A1 | Mobility-Modified Nucleobase Polymers and Methods of Using Same | APPLERA CORPORATION (US) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197907-A1 | Phosphorus-containing compounds & uses thereof | NR5A2, NR2E3, VDR | ALDH1A1 4692/4885MEN1 1917/4885KMT2A 137/4885 |
| US-20070026434-A1 | Mobility-Modified Nucleobase Polymers and Methods of Using Same | PCNA, PNKP, SAMHD1 | ALDH1A1 4308/4885MEN1 2131/4885KMT2A 2782/4885 |
| US-20070190106-A1 | Phosphorus-containing compounds & uses thereof | NR5A2, NR2E3, VDR | ALDH1A1 4692/4885MEN1 1917/4885KMT2A 137/4885 |
| US-20120178714-A1 | Phosphorus-containing Compounds & Uses Thereof | ALPP, ALPI, PHOSPHO1 | ALDH1A1 2663/4885MEN1 453/4885KMT2A 4368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.