Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.60 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.59 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844491 | 0.86 | HTR2A (0.67) | KDM4ERAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL30223611 | 0.82 | HTR2A (0.67) | KDM4EALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL3927394 | 0.82 | HTR2A (0.67) | KDM4EALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL15307679 | 0.81 | HTR2A (0.65) | KDM4EALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL14564006 | 0.80 | RAB9A (0.82) | KDM4ERAB9ANPC1PABPC1PKM | |
| SCHEMBL14564019 | 0.78 | RAB9A (0.97) | KDM4ERAB9ANPC1PABPC1PKM | |
| SCHEMBL21311802 | 0.78 | HTR2A (0.53) | KDM4EATMHTTALDH1A1HTR2A | |
| SCHEMBL8791910 | 0.78 | HTR2A (0.56) | KDM4ERAB9ANPC1PABPC1PKM | |
| SCHEMBL14564012 | 0.77 | RAB9A (0.97) | KDM4ERAB9ANPC1PABPC1PKM | |
| SCHEMBL10309049 | 0.73 | RAB9A (0.59) | KDM4ERAB9ANPC1PABPC1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178769-A1 | NOVEL COMPOUNDS FOR INHIBITING EEF-2 KINASE ACTIVITY | THE UNIVERSITY OF MEDICINE AND DENTISTRY (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178769-A1 | NOVEL COMPOUNDS FOR INHIBITING EEF-2 KINASE ACTIVITY | EEF2K, EEF2, EEF1B2 | KDM4E 1026/4885RAB9A 1227/4885NPC1 3212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.