Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387339 | 0.79 | ALDH1A1 (0.54) | ALDH1A1GAAMAPK1SMN1; SMN2MAPT | |
| SCHEMBL18343921 | 0.78 | ALDH1A1 (0.49) | ALDH1A1GAAMAPK1SMN1; SMN2MAPT | |
| SCHEMBL1241218 | 0.78 | ALDH1A1 (0.49) | ALDH1A1GAAMAPK1SMN1; SMN2MAPT | |
| SCHEMBL3563144 | 0.78 | ALDH1A1 (0.49) | ALDH1A1GAAMAPK1SMN1; SMN2MAPT | |
| SCHEMBL6890038 | 0.78 | CHRNB2 (0.53) | ALDH1A1GAAMAPK1SMN1; SMN2MAPT | |
| SCHEMBL10309259 | 0.75 | ALDH1A1 (0.61) | ALDH1A1GAAMAPK1SMN1; SMN2MAPT | |
| SCHEMBL9122777 | 0.74 | ALDH1A1 (0.59) | ALDH1A1MAPK1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL16870007 | 0.74 | CHRNB2 (0.57) | ALDH1A1GAAMAPK1SMN1; SMN2MAPT | |
| SCHEMBL24769896 | 0.74 | ALDH1A1 (0.46) | ALDH1A1GAAMAPK1SMN1; SMN2MAPT | |
| SCHEMBL15923525 | 0.74 | GAA (0.47) | ALDH1A1GAAMAPK1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178769-A1 | NOVEL COMPOUNDS FOR INHIBITING EEF-2 KINASE ACTIVITY | THE UNIVERSITY OF MEDICINE AND DENTISTRY (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178769-A1 | NOVEL COMPOUNDS FOR INHIBITING EEF-2 KINASE ACTIVITY | EEF2K, EEF2, EEF1B2 | ALDH1A1 3850/4885GAA 2350/4885MAPK1 604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.