Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | AIP | O00170 | 1/20 | 0.33 |
| ▸ | SGTA | O43765 | 1/20 | 0.33 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.33 |
| ▸ | STIP1 | P31948 | 1/20 | 0.33 |
| ▸ | PPP5C | P53041 | 1/20 | 0.33 |
| ▸ | DNAJC7 | Q99615 | 1/20 | 0.33 |
| ▸ | STUB1 | Q9UNE7 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858020 | 0.81 | MAPT (0.39) | ALDH1A1MAPTHPGDGAASMN1; SMN2 | |
| SCHEMBL858019 | 0.81 | MAPT (0.39) | ALDH1A1MAPTHPGDGAASMN1; SMN2 | |
| SCHEMBL4548474 | 0.75 | DRD2 (0.35) | ALDH1A1MAPTHPGDGAA | |
| SCHEMBL2490865 | 0.69 | — | — | |
| SCHEMBL2688028 | 0.69 | NOS3 (0.43) | ALDH1A1MAPTHPGDGAANOS3 | |
| SCHEMBL11400291 | 0.69 | NOS3 (0.37) | ALDH1A1MAPTHPGDGAANOS3 | |
| SCHEMBL12764958 | 0.67 | SMN1; SMN2 (0.36) | ALDH1A1MAPTHPGDGAASMN1; SMN2 | |
| SCHEMBL757145 | 0.66 | SLC6A3 (0.47) | ACHE | |
| SCHEMBL819039 | 0.66 | SLC6A3 (0.47) | ACHE | |
| SCHEMBL11602953 | 0.66 | SMN1; SMN2 (0.39) | ALDH1A1MAPTGAASMN1; SMN2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178750-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178750-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | HCAR1, HCAR2, FFAR1 | ALDH1A1 1106/4885MAPT 2701/4885HPGD 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.