Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 15/20 | 0.44 |
| ▸ | PGR | P06401 | 10/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 9/20 | 0.44 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379406 | 0.84 | NR3C1 (0.48) | NR3C1PGRNR3C2PLOD2 | |
| SCHEMBL1492523 | 0.83 | PLOD2 (0.38) | NR3C1PGRNR3C2PLOD2 | |
| SCHEMBL1492567 | 0.81 | HDAC6 (0.40) | NR3C1PGRNR3C2PLOD2 | |
| SCHEMBL1492624 | 0.81 | DDR1 (0.39) | NR3C1PGRNR3C2PLOD2 | |
| SCHEMBL1492607 | 0.81 | NR3C2 (0.53) | NR3C1NR3C2 | |
| SCHEMBL1492525 | 0.81 | DDR1 (0.40) | NR3C1PLOD2 | |
| SCHEMBL1492608 | 0.80 | PLOD2 (0.38) | NR3C1PGRNR3C2PLOD2AR | |
| SCHEMBL10254048 | 0.80 | PLOD2 (0.38) | NR3C1PGRNR3C2PLOD2 | |
| SCHEMBL14340600 | 0.80 | RIPK1 (0.40) | NR3C1PGRNR3C2PLOD2 | |
| SCHEMBL1492615 | 0.79 | KEAP1 (0.42) | NR3C1NR3C2PLOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8212040-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2012-07-03 | — | — | US | disclosed |