Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.59 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.59 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HK1 | P19367 | 1/20 | 0.57 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29276767 | 0.84 | ALDH1A1 (0.67) | LTA4HMKNK1MKNK2MAPTRAB9A | |
| SCHEMBL10315988 | 0.80 | LTA4H (0.59) | LTA4HMKNK1MKNK2MAPTRAB9A | |
| SCHEMBL10087446 | 0.80 | ALDH1A1 (0.61) | LTA4HMKNK1MKNK2MAPTRAB9A | |
| SCHEMBL16345828 | 0.80 | RAB9A (0.57) | LTA4HMKNK1MKNK2MAPTRAB9A | |
| SCHEMBL474270 | 0.80 | MPL (0.63) | LTA4HMKNK1MKNK2MAPTRAB9A | |
| SCHEMBL4704845 | 0.80 | LTA4H (0.59) | LTA4HMKNK1MKNK2MAPTRAB9A | |
| SCHEMBL10200395 | 0.80 | LTA4H (0.59) | LTA4HMKNK1MKNK2MAPTRAB9A | |
| SCHEMBL10315892 | 0.80 | LTA4H (0.59) | LTA4HMKNK1MKNK2MAPTRAB9A | |
| SCHEMBL16346205 | 0.77 | RAB9A (0.57) | LTA4HMKNK1MKNK2MAPTRAB9A | |
| SCHEMBL16346609 | 0.77 | RAB9A (0.57) | LTA4HMKNK1MKNK2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178766-A1 | FUROPYRIMIDINEDIONE DERIVATIVES AS TRPAI MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178766-A1 | FUROPYRIMIDINEDIONE DERIVATIVES AS TRPAI MODULATORS | TRPA1, TRPV1, TRPC3 | LTA4H 234/4885MKNK1 1595/4885MKNK2 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.