Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.30 |
| ▸ | HTR7 | P34969 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1030887 | 0.89 | CA12 (0.34) | CA12CA1CA2CA9HTR1A | |
| Hydrochloric Acid SCHEMBL1032897 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL1031761 | 0.87 | NPC1 (0.32) | CA12CA1CA2CA9NPC1 | |
| Hydrochloric Acid SCHEMBL5071127 | 0.85 | HTR7 (0.32) | CA12CA1CA2CA9HTR1A | |
| Hydrochloric Acid SCHEMBL1032071 | 0.83 | NPC1 (0.32) | NPC1MAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1030858 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL1033508 | 0.83 | SMN1; SMN2 (0.31) | NPC1MAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1030958 | 0.81 | HTR7 (0.32) | HTR7 | |
| Hydrochloric Acid SCHEMBL1034556 | 0.80 | ADRA2A (0.32) | — | |
| Hydrochloric Acid SCHEMBL6891796 | 0.79 | NPC1 (0.34) | NPC1MAPTRAB9ASMN1; SMN2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567560-B1 | ORGANOMETALLIC TRANSITION METAL COMPOUND, BISCYCLOPENTADIENYL LIGAND SYSTEM, CATALYST SYSTEM AND PROCESS FOR PREPARING POLYOLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2011-01-19 | — | — | EP | disclosed |