Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030837 | 0.88 | NPC1 (0.44) | ALDH1A1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL1029856 | 0.82 | HTT (0.46) | ALDH1A1MAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL1032145 | 0.80 | EPHX2 (0.45) | HTTNPSR1 | |
| SCHEMBL1032310 | 0.80 | ADORA2A (0.42) | ALDH1A1HTTLMNASMN1; SMN2KDM4E | |
| SCHEMBL1028135 | 0.78 | ALDH1A1 (0.53) | ALDH1A1MAPTLMNAKDM4EPOLB | |
| SCHEMBL1031836 | 0.77 | MEN1 (0.43) | HTTLMNASMN1; SMN2POLBKMT2A | |
| SCHEMBL1032776 | 0.76 | KMT2A (0.45) | ALDH1A1MAPTLMNAKDM4EPOLB | |
| SCHEMBL1030586 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MAPTHTTKDM4EPOLB | |
| SCHEMBL1030443 | 0.76 | RAB9A (0.46) | ALDH1A1MAPTLMNASMN1; SMN2KDM4E | |
| SCHEMBL1031019 | 0.76 | PLAAT3 (0.42) | ALDH1A1HTTSMN1; SMN2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |