SCHEMBL1032446

SCHEMBL1032446

Cc1cc(C)c(C(=O)P(=O)(CC(=O)O)C(=O)c2c(C)cc(C)cc2C)c(C)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.42
KDM4E B2RXH2 3/20 0.39
HPGD P15428 2/20 0.39
LMNA P02545 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TAS1R3 Q7RTX0 4/20 0.37
TAS1R1 Q7RTX1 4/20 0.37
TAS1R2 Q8TE23 4/20 0.37
MAPT P10636 2/20 0.35
POLB P06746 1/20 0.35
TSHR P16473 1/20 0.35
ALDH1A1 P00352 1/20 0.34
MAPK1 P28482 1/20 0.34
PGK1 P00558 1/20 0.33
PGK2 P07205 1/20 0.33
USP2 O75604 1/20 0.33
TPMT P51580 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2710988 0.98 GAA (0.41) GAAKDM4EHPGDLMNAL3MBTL1
SCHEMBL1033218 0.84 LMNA (0.38) GAAKDM4EHPGDLMNAL3MBTL1
SCHEMBL691620 0.82 LMNA (0.37) GAAKDM4EHPGDLMNAL3MBTL1
SCHEMBL15637216 0.82 NPSR1 (0.39) KDM4EHPGDLMNAL3MBTL1MEN1
SCHEMBL2499305 0.81 HPGD (0.45) GAAKDM4EHPGDLMNAL3MBTL1
SCHEMBL1030595 0.81 POLB (0.40) KDM4EHPGDLMNAL3MBTL1MEN1
SCHEMBL1038176 0.80 LMNA (0.47) KDM4EHPGDLMNAMEN1KMT2A
SCHEMBL1035650 0.80 TAS1R3 (0.36) KDM4EHPGDLMNAL3MBTL1MEN1
SCHEMBL1039014 0.80 NLRP3 (0.44) GAAKDM4EHPGDLMNAL3MBTL1
SCHEMBL1035616 0.79 KMT2A (0.40) GAAKDM4EHPGDLMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8921444-B2 Process for the modification of polymers, in particular polymer nanoparticles MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) 2014-12-30 US claimed
US-8921442-B2 Ultra fast process for the preparation of polymer nanoparticles MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E. V. (DE) 2014-12-30 US claimed
EP-2421903-B1 POLYMER NANOPARTICLES ETH ZUERICH (CH) 2014-11-19 EP claimed
US-20130261210-A1 ULTRA FAST PROCESS FOR THE PREPARATION OF POLYMER NANOPARTICLES MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) 2013-10-03 US claimed
US-20130261211-A1 PROCESS FOR THE MODIFICATION OF POLYMERS, IN PARTICULAR POLYMER NANOPARTICLES MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) 2013-10-03 US claimed
EP-2630163-A1 ULTRA FAST PROCESS FOR THE PREPARATION OF POLYMER NANOPARTICLES Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2013-08-28 EP claimed
EP-2630164-A1 PROCESS FOR THE MODIFICATION OF POLYMERS, IN PARTICULAR POLYMER NANOPARTICLES Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2013-08-28 EP claimed
US-20120115963-A1 POLYMER NANOPARTICLES ETH ZUERICH (CH) 2012-05-10 US claimed
WO-2012052148-A1 ULTRA FAST PROCESS FOR THE PREPARATION OF POLYMER NANOPARTICLES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2012-04-26 WO claimed
WO-2012052147-A1 PROCESS FOR THE MODIFICATION OF POLYMERS, IN PARTICULAR POLYMER NANOPARTICLES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2012-04-26 WO claimed
EP-4273200-A1 PHOTOINITIATOR PACKAGE COMPRISING SPECIALISED BISACYLPHOSPHINE OXIDE PHOTOINITIATORS AND OPTICAL BRIGHTENER SENSITIZERS IGM Group B.V. (NL) 2023-11-08 EP disclosed
EP-2451847-B1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES IGM GROUP B V (NL) 2021-11-24 EP disclosed
US-10023675-B2 Polymer nanoparticles ETH ZUERICH (CH) 2018-07-17 US disclosed
US-10023675-B2 Polymer nanoparticles ETH ZUERICH (CH) 2018-07-17 US disclosed
US-10023675-B2 Polymer nanoparticles ETH ZUERICH (CH) 2018-07-17 US disclosed
US-20120115963-A1 POLYMER NANOPARTICLES ETH ZUERICH (CH) 2012-05-10 US disclosed
US-20120115963-A1 POLYMER NANOPARTICLES ETH ZUERICH (CH) 2012-05-10 US disclosed
WO-2012052148-A1 ULTRA FAST PROCESS FOR THE PREPARATION OF POLYMER NANOPARTICLES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2012-04-26 WO disclosed
WO-2012052147-A1 PROCESS FOR THE MODIFICATION OF POLYMERS, IN PARTICULAR POLYMER NANOPARTICLES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2012-04-26 WO disclosed
WO-2011003772-A1 POLYMER-BOUND BISACYLPHOSPHINE OXIDES BASF SE (DE) 2011-01-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10023675-B2 Polymer nanoparticles POLQ, POLN, POLA1 GAA 3201/4885KDM4E 4562/4885HPGD 908/4885
US-20120115963-A1 POLYMER NANOPARTICLES POLQ, POLN, POLA1 GAA 3201/4885KDM4E 4562/4885HPGD 908/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.