Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP2 | O95551 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.47 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.47 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10325499 | 1.00 | MAOA (0.50) | MAOALMNAKDM4EKMT2ATDP2 | |
| SCHEMBL10325455 | 1.00 | MAOA (0.50) | MAOALMNAKDM4EKMT2ATDP2 | |
| SCHEMBL6130887 | 0.88 | DRD2 (0.53) | LMNAKDM4EKMT2AADRA1ADRD2 | |
| SCHEMBL16971018 | 0.86 | ACHE (0.47) | LMNAKMT2ADRD2DRD1MEN1 | |
| SCHEMBL15557948 | 0.85 | HCRTR1 (0.47) | LMNAKMT2AMAPTDRD2DRD1 | |
| SCHEMBL16979267 | 0.84 | LMNA (0.46) | LMNAKDM4EKMT2ADRD2DRD1 | |
| SCHEMBL6130836 | 0.83 | LMNA (0.67) | MAOALMNAKDM4EKMT2AKCNN2 | |
| SCHEMBL6130861 | 0.83 | LMNA (0.67) | MAOALMNAKDM4EKMT2AKCNN2 | |
| SCHEMBL16979266 | 0.83 | KMT2A (0.58) | LMNAKDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL15558733 | 0.82 | HCRTR1 (0.45) | LMNAKDM4EKMT2AMAPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815788-B2 | Anti-angiogenic compounds | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2017-11-14 | — | — | US | disclosed |
| US-9815788-B2 | Anti-angiogenic compounds | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2017-11-14 | — | — | US | disclosed |
| US-20170050930-A1 | ANTI-ANGIOGENIC COMPOUNDS | UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2017-02-23 | — | — | US | disclosed |
| US-20170050930-A1 | ANTI-ANGIOGENIC COMPOUNDS | UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2017-02-23 | — | — | US | disclosed |
| EP-2663307-B1 | ANTI-ANGIOGENIC COMPOUND | UNIV DUBLIN (IE) | 2016-08-31 | — | — | EP | disclosed |
| EP-2663307-B1 | ANTI-ANGIOGENIC COMPOUND | UNIV DUBLIN (IE) | 2016-08-31 | — | — | EP | disclosed |
| US-9388138-B2 | Anti-angiogenic compounds | UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2016-07-12 | — | — | US | disclosed |
| US-9388138-B2 | Anti-angiogenic compounds | UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2016-07-12 | — | — | US | disclosed |
| US-20150218100-A1 | ANTI-ANGIOGENIC COMPOUNDS | UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2015-08-06 | — | — | US | disclosed |
| US-20150218100-A1 | ANTI-ANGIOGENIC COMPOUNDS | UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2015-08-06 | — | — | US | disclosed |
| US-8916586-B2 | Anti-angiogenic compound | University College Dublin—National University of Ireland, Dublin (IE) | 2014-12-23 | — | — | US | disclosed |
| US-8916586-B2 | Anti-angiogenic compound | University College Dublin—National University of Ireland, Dublin (IE) | 2014-12-23 | — | — | US | disclosed |
| US-8916586-B2 | Anti-angiogenic compound | University College Dublin—National University of Ireland, Dublin (IE) | 2014-12-23 | — | — | US | disclosed |
| EP-2663307-A1 | ANTI-ANGIOGENIC COMPOUND | University College Dublin National University Of Ireland, Dublin (IE) | 2013-11-20 | — | — | EP | disclosed |
| US-20130289066-A1 | ANTI-ANGIOGENIC COMPOUND | UNIVERSITY COLLEGE DUBLIN - NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2013-10-31 | — | — | US | disclosed |
| US-20130289066-A1 | ANTI-ANGIOGENIC COMPOUND | UNIVERSITY COLLEGE DUBLIN - NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2013-10-31 | — | — | US | disclosed |
| US-20130289066-A1 | ANTI-ANGIOGENIC COMPOUND | UNIVERSITY COLLEGE DUBLIN - NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2013-10-31 | — | — | US | disclosed |
| WO-2012095836-A1 | ANTI-ANGIOGENIC COMPOUND | UNIVERSITY COLLEGE DUBLIN - NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2012-07-19 | — | — | WO | disclosed |
| WO-2012095836-A1 | ANTI-ANGIOGENIC COMPOUND | UNIVERSITY COLLEGE DUBLIN - NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2012-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050930-A1 | ANTI-ANGIOGENIC COMPOUNDS | VEGFA, FLT4, VHL | MAOA 3213/4885LMNA 2551/4885KDM4E 2034/4885 |
| US-20150218100-A1 | ANTI-ANGIOGENIC COMPOUNDS | VEGFA, FLT4, VHL | MAOA 3213/4885LMNA 2551/4885KDM4E 2034/4885 |
| US-20130289066-A1 | ANTI-ANGIOGENIC COMPOUND | VEGFA, FLT4, FLT1 | MAOA 974/4885LMNA 2421/4885KDM4E 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.